Search for dissertations about: "IL-13"

Showing result 6 - 10 of 78 swedish dissertations containing the word IL-13.

  2. 6. Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity

    Author : Martijn Manson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing and potential new therapies for asthma. READ MORE

  4. 7. Investigation of immune cell-derived factors as potential biomarkers in patients with colorectal cancer

    Author : Levar Shamoun; Dick Wågsäter; Jan Dimberg; Kalle Landerholm; Blanka Kolodziej; Richard Palmqvist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gene polymorphism; Colorectal cancer; Immunoregulation; Prognosis; Gene and protein expression; Survival; Zmynd15; Genpolymorfism; Kolorektal cancer; Immunreglering; Prognos; Gen- och proteinuttryck; Överlevnad; Zmynd15; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap; Medical Cell Biology; Medicinsk cellbiologi; Patologi; Pathology;

    Abstract : Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer related death. It is a heterogeneous disease involving multiple molecular pathways that result in differing phenotypes. Individual variability in CRC susceptibility is influenced by genetic variation, such as single nucleotide polymorphisms (SNPs). READ MORE

  5. 8. Studies on cytokine mRNA expression in mononuclear cells in neuroimmunological diseases

    Author : Darius Matusevicius; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), characterized by perivascular accumulation of blood mononuclear cells (MNC) and patchy demyelination. High levels of circulating myelin antigen specific T and B cells, with an accumulation in cerebrospinal fluid (CSF), suggest the involvement of cytokines in the pathogenesis of MS. READ MORE

  6. 9. Regulation of innate and adaptive immune responses by Gram-positive and Gram-negative bacteria

    Author : Anna Martner; Göteborgs universitet; []
    Keywords : Gram-positive; Gram-negative bacteria; Streptococcus pneumoniae; IL-12; autolysin; pneumolysin; CD4 T cells; monocytes macrophages; dendritic cells;

    Abstract : Bacteria are classified as Gram-positive or Gram-negative, depending on their cell wall structure. The role of the bacterial cell wall in immune regulation is the focus of the current work. Most Gram-positive bacteria stimulate monocytes to produce large amounts of IL-12. READ MORE

  7. 10. Immunological interactions between mother and child during pregnancy in relation to the development of allergic diseases in the offspring

    Author : Martina Abelius; Maria Jenmalm; Lennart Nilsson; Marita Troye-Blomberg; Linköpings universitet; []
    Keywords : ;

    Abstract : Background: Pregnancy and allergic disease have both been postulated as T-helper 2 (Th2) phenomena. Thus, the increased propensity of allergic mothers to mount Th2-responses might generate favourable effects on the maintenance of pregnancy, but might also be unfavorable, as fetal exposure to a strong Th2 environment could influence the immune development in the offspring to a Th2-like phenotype, favouring IgE production and possibly allergy development later in life. READ MORE