Search for dissertations about: "IL-1alpha"

Showing result 1 - 5 of 14 swedish dissertations containing the word IL-1alpha.

2. 1. Studies of the tumor microenvironment : Local and systemic effects exerted by the cross-talk between tumor and stroma cells in pancreatic cancer

   Author : Vegard Tjomsland; Marie Larsson; Arne Östman; Linköpings universitet; []
   Keywords : Pancreatic cancer; cancer associated fibroblasts; dendritic cells; IL-1alpha; tumor microenvironment; inflammation; bukspottkörtelcancer; Bukspyttkjertel kreft; MEDICINE; MEDICIN;

   Abstract : Pancreatic cancer is one of the most lethal cancers and despite all research efforts the last 50 years, there are still no effective therapy for this terrible disease. Until quite recently most research in the field of pancreatic duct adenocarcinoma (PDAC) was focused on the tumor cells and mechanisms essential for their proliferation and survival. READ MORE

4. 2. Rheumatoid Arthritis in a 10-Year Perspective, Outcome for Patients Followed from Early Disease

   Author : Elisabet Lindqvist; Reumatologi och molekylär skelettbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; rheumatology locomotion; Skelett; COMP; Skeleton; muscle system; Anti-IL-1alpha; Anti-CCP; Rheumatoid factor isotypes; Mortality; Radiographic progression; Joint damage; Disease activity; HAQ; SOFI; Disability; Prognosis; Rheumatoid arthritis; Outcome;

   Abstract : Rheumatoid arthritis (RA) is characterized by persistent inflammation, progressive joint damage and disability. This thesis describes the outcome after 10 years in a cohort of 183 RA patients (116 women, 67 men) recruited 1985-89. The mean age was 51 years and symptom duration 11 months at inclusion. READ MORE

5. 3. On the role of HMGB1 and IL-1 in tissue barrier defense

   Author : Cecilia Zetterström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The specialized epithelial surfaces of the lymphoepithelial tissue in the airways and the seminiferous epithelium of the testis are sites of host-environmental interaction at the same time as they serve important physiological functions in gas exchange and reproduction. The host response of a broken epithelial barrier requires rapid mechanisms to control the microflora and to prevent invasion of pathogens. READ MORE

6. 4. Calcitonin gene-related peptide in temporomandibular inflammation

   Author : Joakim Carleson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : CGRP; Calcitonin gene-related peptide; neuropeptides; inflammation; temporomandibular joint; masseter muscle; TMJ; TMD; nociception; scratching; neurogenic inflammation.;

   Abstract : Calcitonin gene-related peptide (CGRP) is an important biological mediator and cell-signalling molecule, involved in modulation of the immune system, inflammatory response and pain modulation. During pain and inflammation, sensory nerves are activated, and sensory neuropeptides such as CGRP is released from peripheral and central nerve endings. READ MORE

7. 5. Mechanisms influencing activation and survival of normal and malignant lymphoid cells in the testis

   Author : Mikael von Euler; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acute lymphoblastic leukaemia; testis; cytokines; IL-1; TGFbeta;

   Abstract : Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and the testis is the third most common site of relapse after treatment. Testicular function is regulated by pituitary hormones, but the testicular microenvironment is also locally regulated through cell-cell interactions and by paracrine factors. READ MORE