Search for dissertations about: "IL-1beta"

Showing result 1 - 5 of 71 swedish dissertations containing the word IL-1beta.

  1. 1. Metabolic alterations in patients with self-inflicted aggressive behaviour

    Author : Sofie Westling; Lund Psykiatri; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggression; insulin; glucose; glucagon; deliberate self-harm; IL-1beta; leptin; suicide attempt.;

    Abstract : Self-inflicted aggressive behaviour is a cross diagnostic phenomenon of major clinical relevance in psychiatric setting. Accumulating evidence speaks for a role of metabolic and immunological factors in aggressive behaviour. READ MORE

  2. 2. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

    Author : Karin Gewert; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. READ MORE

  3. 3. Molecular mechanisms and immunomodulatory approaches in acute cystitis

    Author : Daniel Butler; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract infection; acute cystitis; Immunomodulation; IL-1beta; hyper inflammatory disorder; neurokinins;

    Abstract : hand in the fight against resistant microbes. This thesis discusses the feasibility and potential of specific immunotherapy in treating acute bacterial infections and chronic sequels. The infection model is acute cystitis; the most common form of urinary tract infection, affecting millions of patients annually. READ MORE

  4. 4. Regulation of inducible nitric oxide synthase - Consequences in experimental models of bladder disease

    Author : Rebecka Johansson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacy; toxicology; Farmakologi; smooth muscle-myosin heavy chain; Pharmacological sciences; pharmacognosy; farmakognosi; farmaci; actin; BDNF; Rho; aminoguanidine; TNF-alpha; IL-1beta; hypertrophy; differentiation; smooth muscle; bladder; nitric oxide; inducible nitric oxide synthase; toxikologi;

    Abstract : Inducible nitric oxide synthase (iNOS) expression is associated with various pathophysiological conditions in the lower urinary tract. The aims of this thesis have been to investigate the regulation of iNOS in bladder smooth muscle cells and the consequences on neuromuscular regulation, cell growth and differentiation. READ MORE

  5. 5. On the effects of Streptococcal NAD+-glycohydrolase and Streptolysin O on macrophages

    Author : Elsa Westerlund; Värd-patogeninteraktioner; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Innate immunity; macrophage; Streptococcus pyogenes; IL-1beta; Nad -glycohydrolase;

    Abstract : SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. READ MORE