Search for dissertations about: "IL-1beta"

Showing result 11 - 15 of 70 swedish dissertations containing the word IL-1beta.

  2. 11. Expression and regulation of MMP-1 and MMP-3 in human gingival fibroblasts

    Author : Helena Domeij; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Matrix metalloproteinases; tissue inhibitor of metalloproteinases; gingival fibroblasts; monocytes; periodontal diseases;

    Abstract : Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes collectively responsible for the metabolism of extra cellular matrix components. Disturbance of the physiological balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), is implicated in several inflammatory diseases characterized by tissue degradation. READ MORE

  4. 12. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

    Author : Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. READ MORE

  5. 13. mPGES-1 : a key regulator of fever and neonatal respiratory depression

    Author : Sipra Saha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Prostaglandins are potent lipid mediators, synthesized de novo from arachidonic acid (AA) upon cell activation. AA is oxidized by the cyclooxygenase isoenzymes (COX-1 and COX-2) to form PGH2, the common substrate for downstream enzymes involved in prostaglandin biosynthesis. READ MORE

  6. 14. Inflammation modulating effects of prostaglandins and omega-3 fatty acids

    Author : Inger Vedin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Omega-(omega6) and omega-3 fatty acids (FA) and their metabolites (eikosanoids, such as prostaglandins, PG) are important modulators of immune and inflammatory responses in various ways. The aim of this thesis was to assess some in vitro and ex vivo effects of these lipids on blood leukocytes. READ MORE

  7. 15. Mechanisms influencing activation and survival of normal and malignant lymphoid cells in the testis

    Author : Mikael von Euler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute lymphoblastic leukaemia; testis; cytokines; IL-1; TGFbeta;

    Abstract : Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and the testis is the third most common site of relapse after treatment. Testicular function is regulated by pituitary hormones, but the testicular microenvironment is also locally regulated through cell-cell interactions and by paracrine factors. READ MORE