Search for dissertations about: "IL-2"

Showing result 6 - 10 of 199 swedish dissertations containing the word IL-2.

2. 6. T cell Tolerance - Cellular and molecular features of immune regulation

   Author : Susanna Grundström; Immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; JAK STAT.; NFkB; suppression; IL-2; superantigen; T cells; tolerance;

   Abstract : The immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. READ MORE

4. 7. Experimental modulation and suppression of anti-allograft immune response

   Author : Öyvind Östraat; Malmö Institutionen för kliniska vetenskaper; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; linomide; leflunomide; cyclophosphamide; mycophenolate mofetil; azathioprine; thalidomide; cyclosporin A; ciprofloxacin; flow cytometry; production; IL-2; Rat cardiac transplantation; allograft; Immunology; serology; transplantation; Immunologi; serologi;

   Abstract : Abstract The objective of this investigation was to characterise the immunomodulatory or immunosuppressive effects of single drug treatment and the potential synergistic or additive effects of combined treatment with the focus on ciprofloxacin, thalidomide, mycophenolate mofetil, azathioprine, cyclophosphamide or leflunomide added to cyclosporin A (CyA). A rat cardiac transplant model was used to study graft survival and the influence on lymphocytes was evaluated by in vitro tests. READ MORE

5. 8. Specific and nonspecific immune mechanisms in human gut : a comparative study of normal and ulcerative colitis intestine

   Author : Moorix Mo-Wai Yeung; Sten Hammarström; Marie-Louise Hammarström; Marita Troye-Blomberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestine; ulcerative colitis; lymphoid aggregates; intraepithelial lymphocytes; lamina propria lymphocytes; γδT-cells; cytokines; IL-2; carcinoembryonic antigen; biliary glycoprotein; epithelial cells; glycocalyx;

   Abstract : The intestine, with its large mucosal surface area, digests and absorbs food nutrients and maintains a beneficial microbial flora in the colon. Local protective immune responses against intestinal pathogens ensure the survival of the individual. These immune reactions are both specific and non-specific in nature. READ MORE

6. 9. Islet xenotransplantation : An immunological study in the pig-to-mouse model

   Author : Birgitta Benda; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; xenotransplantation; porcine; islet; in vivo; knock-out mouse; immunohistochemistry; CsA; MDL 201; 449A; Ig; FcR; IL-6; perforin; granzyme B; macrophage; eosinophilic granulocyte; T cell; TCR; IFN- g; TNF- a; IL-2; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

   Abstract : Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. READ MORE

7. 10. LOAd703 and beyond : Advancing immunostimulatory gene therapy for cancer

   Author : Jessica Wenthe; Angelica S. Loskog; Marco Donia; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Immunotherapy; Gene therapy; Oncolytic virus; Adenovirus; CAR T cells; Immune checkpoint inhibition; CD40L; 4-1BBL; IL-2;

   Abstract : In the last decade, immunotherapy has come into the limelight of cancer treatments. Immunotherapy aims to stimulate the body’s own immune system to create or reinvigorate anti-tumor immune responses. READ MORE