Search for dissertations about: "INDUCED POINT MUTATIONS"

Showing result 1 - 5 of 47 swedish dissertations containing the words INDUCED POINT MUTATIONS.

2. 1. p53 inactivation by point mutations and splice site mutations in human and mouse tumors

   Author : Kristinn P Magnússon; Karolinska Institutet; Karolinska Institutet; []
   Keywords : p53; Burkitt Iymphoma; apoptosis; alternative splicing; mutation; ascites;

   Abstract : The p53 tumor suppressor gene is frequently mutated in human tumors. p53 induces cell cycle arrest and/or apoptosis in response to cellular stress, such as DNA damage, hypoxia and certain activated oncogenes like c-myc. The status of p53 in Burkitt's Iymphoma (BL) cell lines was investigated. The majority of BL lines expressed mutated p53 protein. READ MORE

4. 2. Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities

   Author : Sausan Moharram; Avdelningen för translationell cancerforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LEUKEMIA; AML; Mutations; FLT3; Signlaing;

   Abstract : Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. READ MORE

5. 3. Mechanisms involved in amyloid induced cytotoxicity

   Author : Johan Östman; Lars Lannfelt; Umeå universitet; []
   Keywords : amyloid; transthyretin; cytotoxicity; apoptosis; caspases; aggregation; molekylärbiologi; Molecular Biology;

   Abstract : Amyloidoses comprise a group of diseases where normal or mutated protein precipitates into amyloid fibrils. The deposition of fibrils causes dysfunction of organs and toxicity to nervous tissue. Up to date, 24 different proteins and peptides are known to be able to form amyloid fibrils. READ MORE

6. 4. Hearing impairment and deafness : genetic and environmental factors - interactions - consequences : a clinical audiological approach

   Author : Per-Inge Carlsson; Erik Borg; Berth Danermark; Claes Möller; Örebro universitet; []
   Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Disability studies; hereditary hearing impairment; deafness; noise induced hearing loss; Deaf community; connexin mutations; oxidative stress genes; family history of hearing impairment; audiological rehabilitation; audiological medicine; Handikappforskning; Disability research; Handikappsforskning; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; Social sciences; Socialvetenskap; Medicinsk handikappvetenskap; Medical Disability Research;

   Abstract : OBJECTIVES - Hearing impairment (HI) can be due to genetic or environmental factors, e.g. noise. More than 50% of HI cases are thougt to be hereditary. READ MORE

7. 5. Molecular Pharmacology and Structure Function Modelling of the Leukotriene B4 Receptor BLT1

   Author : Alan Sabirsh; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Pharmacological sciences; fluidity; redox; chemotaxis; luciferase; calcium; ligand binding; point mutation; modelling; antibody; BLT1; leukotriene; pharmacology; GPCR; G-protein; receptor;

   Abstract : Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. READ MORE