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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Anticoagulation treatment in patients with a mechanical heart valve

    Author : Bartosz Grzymala-Lubanski; Anders Själander; Peter J. Svensson; David Bergqvist; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mechanical heart valve; anticoagulation; warfarin; Time in Therapeutic Range TTR ; INR variability;

    Abstract : BackgroundEvery year about 2,500 patients in Sweden undergo surgery for heart valve disease, primarily in the aortic valve.  In contrast to the mitral valve, which can be repaired in 70% of the cases, the aortic valve is normally replaced by a mechanical or biological prosthesis. READ MORE

  4. 2. Warfarin treatment quality in stroke prevention

    Author : Fredrik Björck; Anders Själander; Peter Svensson; Per Wester; Christine Kremer; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticoagulation; atrial fibrillation; complications; international normalized ratio INR variability; persistence; stroke; time in therapeutic range TTR ; treatment quality; warfarin; cardiovascular disease; hjärt- och kärlforskning;

    Abstract : BackgroundIschemic stroke is a serious condition often associated to presence of atrial fibrillation (AF). Use of anticoagulants for AF patients greatly reduces the risk of stroke. Warfarin is the most commonly used anticoagulant in Sweden. The aim of this thesis was to study the impact of warfarin treatment quality in Swedish stroke prevention. READ MORE

  5. 3. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

    Author : Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. READ MORE

  6. 4. Efficacy and safety of warfarin treatment in venous thromboembolic disease

    Author : Per Sandén; Anders Själander; Peter Svensson; Gerd Lärfars; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Warfarin; Venous thromboembolism; Bleeding;

    Abstract : BackgroundAs a major cause of morbidity and mortality treatment of venous thromboembolism is important, with the correct use of anticoagulants it is possible to greatly reduce both mortality and morbidity. Warfarin is among the most widely used anticoagulants being effective in treatment and prevention of venous thromboembolism with few negative side effects other than bleeding complications. READ MORE

  7. 5. Coagulation in children with liver disease

    Author : Maria Magnusson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : FVIIa;

    Abstract : About 100 new children in Sweden require care at a tertiary pediatric ward each year for severe liver disease. These children are at risk for both severe gastrointestinal bleeding, which may be life threatening, and intra- or extrahepatic thrombosis. READ MORE