Search for dissertations about: "INS-1"

Showing result 1 - 5 of 20 swedish dissertations containing the word INS-1.

  1. 1. Enterostatin - target proteins and intracellular mechanisms. Function in food intake and energy metabolism

    University dissertation from Karin Berger, BMC B11, 221 84 Lund, Sweden

    Author : Karin Berger; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; energy metabolism; insulin; uncoupling protein; beta-casomorphin; opiate; SK-N-MC; INS-1; Medicin människa och djur ; Medicine human and vertebrates ; fat intake; F1F0-ATP synthase; appetite; enterostatin; satiety; obesity;

    Abstract : Hunger and satiety are the results of complex neural events that involve several neurotransmitters and peptides. Enterostatin is an appetite-regulating peptide released in the intestine in response to fat ingestion. Enterostatin specifically decreases fat intake, but has also metabolic effects like inhibition of insulin secretion. READ MORE

  2. 2. Intracellular signaling of phosphorylated insitol compounds : A study in pancreatic beta-cells and hippocampal neurons

    University dissertation from Stockholm : Karolinska Institutet, Department of Molecular Medicine

    Author : Jia Yu; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; InsP6; L-type Ca 2 channel; hippocampal neuron; Ins 1; 4; 5 P3; Ca2 ; cyt-MIPP; pancreatic beta-cell; PtdIns 3; 4; 5 P3; Ptdlns 3; 5 P2.;

    Abstract : The family of phosphorylated inositol compounds consists of soluble cytosolic inositol phosphates and insoluble inositol phospholipids, localized in cellular membranes and the nuclear matrix. Although inositol phospholipids only account for 5-10% of total plasma membrane lipids, these compounds and their inositol phosphate derivatives play an important role in a broad range of cellular processes including intracellular Ca 2+ signalling, ion channel regulation, vesicle trafficking, both exo- and endocytosis, cell growth and apoptosis. READ MORE

  3. 3. Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP

    University dissertation from Experimental Medical Science, Lund University

    Author : Ulrika Krus; Lund University.; Lunds universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; Endocrinology; pyruvate dehydrogenase kinase; beta-cells; pyruvate carboxylase; diabetology; Endokrinologi; sekretion; diabetologi; diabetes;

    Abstract : Type 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. READ MORE

  4. 4. The impact of glucotoxicity on pancreatic β-cell function

    University dissertation from Diabetes Centre, Lund University

    Author : Sarheed Jabar Muhammed; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Abstract : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. READ MORE

  5. 5. Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function

    University dissertation from Islet cell exocytosis, Dept of Clinical Scinces

    Author : Vishal Ashok Salunkhe; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; exocytosis; Ca2 ; miR-375; miR-335; rosuvastatin; voltage-gated Na channels; STXBP1; SNAP25; SYT11; glucose homeostasis; beta cell function;

    Abstract : Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. READ MORE