Search for dissertations about: "INS-1"
Showing result 11 - 15 of 27 swedish dissertations containing the word INS-1.
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11. Metabolic signals in the regulation of insulin release
Abstract : In the present thesis, an attempt was made to elucidate the role of some of the glucose-induced intracellular metabolic effector signals in insulin secretion and to develop new applications that will enable further investigations of oscillatory signalling and secretion from pancreatic ß-cells. The sequence of early metabolic and ionic events was examined in clonal pancreatic insulin secreting cells (HIT) in response to glucose stimulation. READ MORE
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12. From the pancreatic beta cell to the endothelium:Pathophysiological aspects of Type 2 Diabetes
Abstract : The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. READ MORE
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13. Innate immunity in diabetes mellitus. Complement components C4BP and C3 promote survival of β cells under metabolic challenges
Abstract : The Complement system is a main effector mechanism of the innate immune system, acting to enhance clearance of pathogens, but also aids removal of biological debris from the body, including immunocomplexes, apoptotic/necrotic cells and protein aggregates. Complement regulators serve to prevent excessive inflammation and their interaction with the same materials targeted by the complement system results in ‘silent’ cleaning of wastes. READ MORE
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14. Synthesis of inositolphosphoglycans found in Trypanosoma cruzi and development of novel carbohydrate monomolecular layers
Abstract : In this thesis, synthetic carbohydrate chemistry has been utilized to contribute to the fundamental understanding of three biological relevant areas. These include parasite cell-membrane glycoconjugates, protein-resistant surfaces and antifreeze glycoproteins. READ MORE
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15. Synthesis and Development of Methods for Preparation of Inositolphosphoglycans, Glycoglycerolipids and Glycerophospholipids
Abstract : This thesis describes the synthesis of a series of myo-inositol-containing oligosaccharides, and the exploration of using the chiral epoxide (S)-glycidol in short synthetic routes to glycoglycerolipids and glycerophospholipids.In chapter 2, synthesis of the core heptasaccharyl myo-inositol Galp(α1-6)Galp(α1 -3)Galf(β1-3)[Glcp(α1-P04-6)Manp](α1-3)Manp(α1-4)GlcNp(α1-6)Ins-1-P04, found in the lipophosphoglycans of Leishmania parasites, is described. READ MORE