Search for dissertations about: "INS-1"

Showing result 6 - 10 of 27 swedish dissertations containing the word INS-1.

  2. 6. Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function

    Author : Vishal Ashok Salunkhe; Diabetes - öcellsexocytos; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; exocytosis; Ca2 ; miR-375; miR-335; rosuvastatin; voltage-gated Na channels; STXBP1; SNAP25; SYT11; glucose homeostasis; beta cell function;

    Abstract : Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. READ MORE

  4. 7. Cereal- and Microbial Phytases. Phytate Degradation, Mineral Binding and Absorption

    Author : Maria Türk; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; mineral binding; iron absorption; cereals; phytate degradation; phytase; dietary phytases; S cerevisiae; A niger;

    Abstract : Cereal foods contain large amounts of phytate (myo-inositol hexaphosphate; IP6), which is the major storage form of phosphorus, in the plant. IP6 possesses a high potential for chelating minerals, such as Fe 2+, Zn2+, Mg2+ and Ca2+. READ MORE

  5. 8. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

    Author : Jones Ofori; Diabetes - öcellsexocytos; []
    Keywords : T2D; insulin secretion; exocytosis; ncRNAs; GAS5; miR-152; miR-335; miR-130a b; miR-375; STXBP1; SNAP25; SYT13; PDHA1; PDX1; glucocortiocoid; beta cell function; glucose metabolism;

    Abstract : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. READ MORE

  6. 9. The role of cocaine- and amphetamine-regulated transcript in endocrine cells

    Author : Liliya Shcherbina; Neuroendokrin cellbiologi; []
    Keywords : Type 2 Diabetes; T2D; cocaine and amphetamine-regulated transcript; CART; beta-cell; K-cell; L-cell; insulin; GIP; GLP-1; incretin hormones;

    Abstract : Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. READ MORE

  7. 10. Regulation of insulin secretion in diabetes: Molecular mechanism and applications

    Author : Rui Wu; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin production secretion; CaV channels; DEGs; aging; magnetic field;

    Abstract : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). READ MORE