Search for dissertations about: "IRF family"

Found 3 swedish dissertations containing the words IRF family.

  2. 1. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors

    Author : Marina Tshuikina Wiklander; Fredrik Öberg; Kenneth Nilsson; Ugo Testa; Uppsala universitet; []
    Keywords : Medical sciences; IRF family; ICSBP IRF8; epigenetics; ATRA; TNFα; histone modifications; methylation; transcription; MEDICIN OCH VÅRD;

    Abstract : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. READ MORE

  4. 2. Crimean-Congo hemorrhagic fever virus : interferon-induced antiviral mechanisms and immune evasion strategies

    Author : Ida Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The Bunyaviridae family is the largest virus family consisting of more than 350 viruses. Despite the increasing knowledge regarding the biology of members of this family, little is known about Crimean-Congo hemorrhagic fever virus (CCHFV), a virus classified within the Nairovirus genus and the causative agent of a severe hemorrhagic fever in humans with high mortality. READ MORE

  5. 3. The role of interferon-regulated genes in the immune system

    Author : Maria Sjöstrand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Type I interferons (IFNs) are potent inducers of the first-line defense against pathogens. Their activity leads to the up- and downregulation of a large number of genes with various effects on the immune system, including direct effects on the pathogens. READ MORE