Search for dissertations about: "IRF8"
Showing result 1 - 5 of 13 swedish dissertations containing the word IRF8.
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1. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
Abstract : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. READ MORE
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2. Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus
Abstract : Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. READ MORE
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3. Functional analysis of intestinal dendritic cells
Abstract : .... READ MORE
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4. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors
Abstract : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. READ MORE
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5. Searching for WT1 target genes in leukemic cell lines
Abstract : .... READ MORE