Search for dissertations about: "IRK"

Found 2 swedish dissertations containing the word IRK.

  2. 1. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

    Author : Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

    Abstract : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. READ MORE

  4. 2. Runge-Kutta Solution of Initial Value Problems: Methods, Algorithms and Implementation

    Author : Hans Olsson; Institutionen för datavetenskap; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Computer science; stiffness; software; computational process; differential algebraic equations; ordinary differential equations; Runge-Kutta; initial value problems; time-stepping; system; kontroll; numerisk analys; Datalogi; control; numerical analysis; systems;

    Abstract : The last decades have seen a strongly increasing use of computers for modeling larger and more complex systems. This has been made possible by a combination of increasing computer power and easy-to-use graphical modeling environments and libraries of components. READ MORE