Search for dissertations about: "IRS1"

Showing result 1 - 5 of 15 swedish dissertations containing the word IRS1.

  1. 1. Molecular Genetic Studies on Prostate and Penile Cancer

    Author : Patiyan Andersson; Peter Söderkvist; Mattias Höglund; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; IRS1; penile cancer; hTERT; FHIT; PIK3CA; HRAS; KRAS; NRAS; BRAF; Oncology; Onkologi;

    Abstract : This thesis is comprised of two parts. In the first part we study the influence of four frequently disputed genes on the susceptibility for developing prostate cancer, and in the second part we attempt to establish a basic understanding of the molecular genetic events in penile cancer. READ MORE

  2. 2. Foxf2 and Foxc2, two transcription factors that regulate adipocyte metabolism

    Author : Rickard Westergren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : forkhead genes; insulin signaling; glucose metabolism; adipose tissue; angiogenesis; Foxc2; Foxf2; Irs1; insulin resistance; Ang-2;

    Abstract : Type 2 diabetes is the most common metabolic disorder today and has reached epidemic proportions in many countries. Diet-induced insulin resistance plays a central role in the development of type 2 diabetes. READ MORE

  3. 3. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes

    Author : Anna Danielsson; Peter Strålfors; Fredrik Nyström; Lena Stensson; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipocytes; type 2 diabetes; insulin; insulin resistance; insulin signalling; phosphorylation; insulin receptor substrate 1; feedback control; Medical cell biology; Medicinsk cellbiologi;

    Abstract : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. READ MORE

  4. 4. Caveolae structure and importance in insulin action

    Author : Hans Thorn; Johan Thyberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Type II diabetes is a disease characterized by chronic hyperglycaemia and abnormalities in lipid metabolism that affects approximately 5% of the population in the Western World. Caveolae are invaginations of the plasma membrane, described as 25-150 nm omega shaped structures, which are enriched in cholesterol, sphingolipids and the constituent protein caveolin. READ MORE

  5. 5. A molecular approach to insulin signalling and caveolae in primary adipocytes

    Author : Karin Stenkula; Fredrik Nyström; Peter Strålfors; Peter Arner; Linköpings universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; caveolae; insulin signalling; adipocytes; Medical cell biology; Medicinsk cellbiologi;

    Abstract : The prevalence of type II diabetes is increasing at an alarming rate due to the western world lifestyle. Type II diabetes is characterized by an insulin resistance distinguished by impaired glucose uptake in adipose and muscle tissues. READ MORE