Search for dissertations about: "IRS1"

Showing result 6 - 10 of 17 swedish dissertations containing the word IRS1.

  2. 6. Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scan and Candidate Genes to Genome Wide Association Studies

    Author : Marketa Sjögren; diabetes och endokrinologi Genomik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Type 2 diabetes (T2D) and metabolic syndrome (MetS) are major health problems associated with cardiovascular disease. Both diseases are influenced by a combination of genetic and environmental factors. The aim of this thesis was to identify genetic risk factors for T2D, particularly T2D associated with obesity, and for MetS. READ MORE

  4. 7. Insulin signaling in primary adipocytes in insulin sensitive and insulin resistant states

    Author : Siri Aili Fagerholm; Peter Strålfors; Mats Söderström; Ulf Smith; Linköpings universitet; []
    Keywords : ;

    Abstract : Increasing numbers of people world-wide develops the disease type 2 diabetes. Development of type 2 diabetes is characterized by a shift from an insulin sensitive state to an insulin resistant state in peripheral insulin responding organs, which originates from the development of insulin resistance in the adipose tissue. READ MORE

  5. 8. Insulin Signaling in Human Adipocytes a Systems Biology Approach

    Author : Cecilia Brännmark; Peter Strålfors; Gunnar Cedersund; Peter Arner; Linköpings universitet; []
    Keywords : ;

    Abstract : Obesity and a sedentary life style are associated with type 2 diabetes, a disease starting with insulin resistance in the adipose tissue, which spreads to the whole body. Despite large research efforts to understand the insulin signaling system, there is little knowledge of the mechanisms behind insulin resistance and type 2 diabetes developments. READ MORE

  6. 9. Roles of PI3-kinase and ARAP2 in regulating glucose metabolism

    Author : Aditi Chaudhari; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PI3-kinase; Type 2 diabetes; ARAP2; Lipid droplets; metabolism;

    Abstract : Insulin signaling is mediated by a complex, highly integrated network which functions to control multiple metabolic and growth processes throughout the organism. A key enzyme in the insulin signaling network is phosphatidylinositol 3-kinase (PI3-kinase). READ MORE

  7. 10. Methanol Masers as Signposts of Star Formation and VLBI Observations of Coronal Emission from Young Stars

    Author : Michele Pestalozzi; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : Using a consistent survey of the galactic plane at 6.7 GHz as a starting point, this thesis reports on the observational as well as theoretical results achieved by extensively studying of the phenomenon of class II methanol masers. The general catalogue of 6. READ MORE