Search for dissertations about: "ISG"

Found 4 swedish dissertations containing the word ISG.

  1. 1. Viperin vs. tick-borne encephalitis virus mechanism of a potent antiviral protein

    University dissertation from Umeå : Umeå University

    Author : Kirstin Vonderstein; Umeå universitet.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus; TBEV; type-I interferon; IFN; Interferon-stimulated gene; ISG; viperin; GBF1; CIAO1; antiviral protein; genome replication; particle release; capsid;

    Abstract : Tick-borne encephalitis virus (TBEV) is a very important virus medically, causing mild or severe encephalitis often with long-lasting sequelae. Treatment of tick-borne encephalitis is limited to supportive care, and antiviral drugs are much needed.The type-I interferon (IFN) system is the first line of host defense against many viruses. READ MORE

  2. 2. Interplay between tick-borne encephalitis virus and the host innate immunity

    University dissertation from Umeå : Umeå University

    Author : Chaitanya Kurhade; Umeå universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Flavivirus; IPS-1; Interferon; Viperin; mikrobiologi; Microbiology;

    Abstract : Flaviviruses are important emerging and re-emerging arthropod-borne pathogens that cause significant morbidity and mortality in humans. It consists of globally distributed human pathogens such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZIKV). READ MORE

  3. 3. The role of the type I interferons and viperin during neurotropic flavivirus infection

    University dissertation from Umeå : Umeå universitet

    Author : Richard Lindqvist; Umeå universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TBEV; Flavivirus; Interferon; Neurotropic; Viperin;

    Abstract : Flaviviruses are globally distributed pathogens that cause millions of human infections annually. One of the most detrimental outcomes of flavivirus infection is encephalitis, which is caused by neurotropic flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), and Tick-borne encephalitis virus (TBEV). READ MORE

  4. 4. Fc receptors and feedback enhancement of antibody responses

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Wernersson; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; mouse; transgenic knockout; immune regulation; B lymphocytes; Fc receptors; IgG; IgE; FcgRI; FcgRII; FcgRIII; CD23; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Abstract : Antibodies are important for the defence against microorganisms, but are also involved inpathological reactions such as allergy or autoimmunity. The exact mechanisms involved inregulation of antibody responses is still largely unknown. In this thesis, immune regulationby antibodies and the receptors they bind to (FcR), were investigated. READ MORE