Search for dissertations about: "Ian Nicholls"

Showing result 1 - 5 of 12 swedish dissertations containing the words Ian Nicholls.

  1. 1. Towards the Rational Design of Molecularly Imprinted Polymers

    Author : Håkan S Andersson; Ann-Christin Koch-Schmidt; Ian A Nicholls; Klaus Mosbach; Richard F Venn; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Thermodynamics; Molecular Recognition; Polyvalency; Cooperativity; Electrostatic Interactions; Hydrophobic Effect; Chromatography; Frontal Analysis; HPLC; Spectroscopy; Molecularly Imprinted Polymer; Molecular Imprinting; Crown Ether; Template Polymerisation; Cyclodextrin; Biochemistry; Metabolism; Biokemi; Biotechnology; Bioteknik; molecular recognition; host-guest chemistry; molecular imprinting; Biokemi; Biochemistry;

    Abstract : Molecular imprinting is a technique by which polymeric materials selective for a given target molecule can be created through a casting procedure. Functionalised monomers are added to a solution of molecular templates. READ MORE

  2. 2. Towards new computational tools for predicting toxicity

    Author : Swapnil Chavan; Ian Nicholls; Scott Boyer; Linnéuniversitetet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Acute toxicity; chronic toxicity; hERG; k-NN; LD50; LOEL; Munro database; QSAR; read-across; toxicity; Medicinsk kemi; Medical Chemistry;

    Abstract : The toxicological screening of the numerous chemicals that we are exposed to requires significant cost and the use of animals. Accordingly, more efficient methods for the evaluation of toxicity are required to reduce cost and the number of animals used. READ MORE

  3. 3. Signal Enhancement by Dynamic Polymers in Quartz Crystal Microbalance Applications

    Author : Gunnar Dunér; Olof Ramström; Ian Nicholls; Andra Dedinaite; KTH; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Signal enhancement; QCM; polyelectrolytes; hydrogel; iniferter; photopolymerization; dynamic polymers; Chemistry; Kemi;

    Abstract :  This licentiate thesis presents studies of signal enhancement by dynamic polymers in quartz crystal microbalance (QCM) applications. The aim of the study has been to determine the potential for the use of polymers on QCM sensors for signal enhancement in molecular interaction studies. READ MORE

  4. 4. QCM-based sensing using biological and biomimetic interfaces

    Author : Louise Elmlund; Ian Nicholls; Teodor Aastrup; Jesper Wiklander; Kristina Nilsson-Ekdahl; Håkan Andersson; Susanne Wikman; Alessandra Maria Bossi; Linnéuniversitetet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Quartz crystal microbalance; molecularly imprinted polymers; phage display; interactions; artificial receptors; recognition; selectivity;

    Abstract : The objective of this thesis was to explore novel approaches for studying molecular recognition at biological and biomimetic surfaces using the quartz crystal microbalance (QCM) biosensor technique. The first two papers focused on the synthesis and study of biotin selective polymer films prepared using the molecularly imprinted polymer (MIP) technique. READ MORE

  5. 5. Fundamental Studies on Molecularly Imprinted Materials

    Author : Kerstin Golker; Ian A. Nicholls; Ken J. Shea; Linnéuniversitetet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Chemometrics; molecular dynamics; molecularly imprinted polymer; molecular imprinting; morphology; polymer; principal component analysis;

    Abstract : The thesis focuses on fundamental studies aimed at elucidating factors that influence molecularly imprinted polymer (MIP) formation and ligand recognition. To this end, a series of computational techniques, in particular chemometrics and molecular dynamics (MD) in conjunction with polymer synthesis and physical characterization studies have been employed. READ MORE