Search for dissertations about: "IdeS"
Showing result 1 - 5 of 10 swedish dissertations containing the word IdeS.
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1. Studies on secreted cysteine proteases of Streptococcus pyogenes : IdeS and SpeB
Abstract : The pathogen Streptococcus pyogenes is a significant cause of human morbidity and mortality. Most of the work in this thesis is focused on streptococcal virulence factor IdeS, but the thesis also features work on SpeB, another streptococcal virulence factor. READ MORE
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2. The streptococcal IgG degrading enzyme IdeS : studies on host-pathogen interactions
Abstract : The important human pathogen Streptococcus pyogenes causes both mild infections such as pharyngitis and impetigo but also severe life threatening invasive infections. Specific antibodies (IgG) recognize pathogens and are important mediators for pathogen clearance by the immune defence. S. READ MORE
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3. Streptococcal immunoglobulin degrading enzymes of the IdeS and IgdE family
Abstract : Bacteria of the genus Streptococcus are common asymptomatic colonisers of humans and animals. As opportunistic pathogens they can however, depending on their host’s immune status and other circumstances, cause mild to very severe infections. READ MORE
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4. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations
Abstract : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. READ MORE
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5. Analysis of the molecular interplay between Streptococcus pyogenes and its human host
Abstract : The common human pathogen Streptococcus pyogenes is the causative agent of numerous mild and severe clinical conditions. It expresses a number of secreted or cell wall-anchored proteins that modulate the human immune system and facilitate colonization and spread of the pathogen in the human host. During S. READ MORE