Search for dissertations about: "IgA class-switch recombination"

Showing result 1 - 5 of 7 swedish dissertations containing the words IgA class-switch recombination.

  2. 1. Intestinal IgA synthesis: Localization and requirements for IgA class switch recombination

    Author : Peter Bergqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgA; Intestine; Gut associated lymphoid tissue; class switch recombination; CD40; germ free;

    Abstract : Production of IgA at mucosal surfaces is one of the most striking features of the mucosal immune system. Despite that IgA was first discovered in the 1950’s and secretory IgA described in gut secretions and breast milk in the mid 1960’s we still have limited information about the sites and exact requirements for IgA class switch recombination. READ MORE

  4. 2. Regulation of gut IgA induction by helper T cells

    Author : Inta Gribonika; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunology; secretory IgA; T regulatory cells; T follicular helper cells; Th17 cells; Peyer s patches; IgA class-switch recombination; germinal centers;

    Abstract : The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. READ MORE

  5. 3. Role of DNA repair in class switch recombination and somatic hypermutation

    Author : Likun Du; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Class switch recombination (CSR) and somatic hypermutation (SHM), occurring in the germinal center, are two important processes for B cell development. Both are initiated by activation-induced cytidine deaminase (AID), through deamination of the C residues in the variable and switch regions of the immunoglobulin locus, resulting in either in single stranded or double stranded DNA breaks. READ MORE

  6. 4. Immunoglobulin isotype switching in health and disease

    Author : Berivan Baskin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Immunoglobulin isotype switching is the process where the Cmy region, initially located downstream of the VDJ region is replaced by another constant region gene. Class switch recombination takes place between switch (S) regions, composed of tandem repeats of short unit sequences, located 5 of each CH gene, except for Cdelta. READ MORE

  7. 5. Studies on Molecular Genetics of B cell Development

    Author : Panagiotis Tsapogas; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin; gene expression; B cell; EBF; class switching; TGF-beta; Immunology; transplantation; serologi; Immunologi; serology;

    Abstract : The development of immature progenitor cells into highly differentiated effector cells is a process central in modern medicine with applications in the fields of cell therapy as well as oncology. This thesis is focused on the molecular mechanisms that control the development of B lymphocytes. READ MORE