Search for dissertations about: "Imatinib"

Showing result 21 - 25 of 55 swedish dissertations containing the word Imatinib.

  2. 21. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis

    Author : Johanna Andersson; Göteborgs universitet; []
    Keywords : Gastrointestinal stromal tumor GIST ; neurofibromatosis type I NF1 ; mutation; prognosis; denaturating high performance liquid chromatography dHPLC ; sequencing; KIT; PDGFRA; NF1;

    Abstract : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. READ MORE

  4. 22. Mathematical model development to investigate the pharmacokinetic variability of two anticancer drugs

    Author : Martin Fransson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pharmacokinetic variability in a population is the variability in plasma drug concentrations among individuals. It may, for instance, be caused by differences in genes coding for drug-transport proteins and metabolizing enzymes, amount of body fat, age, sex, patient compliance, diet or disease progression. READ MORE

  5. 23. Role of ion and water channels for lung growth in congenital diaphragmatic hernia

    Author : Andreas Ringman Uggla; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Early lung development is based on a continuous cross-talk of growth and transcription factors between the developing lung bud and the surrounding parenchyma. Throughout fetal life, pulmonary growth and differentiation depend on Cl- driven lung liquid secretion. READ MORE

  6. 24. Markers for clinical outcome and therapy response in soft tissue sarcomas

    Author : Jan Åhlen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Soft-tissue sarcomas (STSs) constitute a heterogeneous group of rare but aggressive tumors that originate from mesenchymal cells in almost any part of the body. Gastrointestinal stromal tumor (GIST), located in the gastrointestinal tract, is the most common type of STS. READ MORE

  7. 25. Cancer and cancer stem cell targeting agents : A focus on salinomycin and apoptin

    Author : Jaganmohan Reddy Jangamreddy; Marek Los; Karin Roberg; Anna-Lotta Hallbeck; Boris Zhivotovsky; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Current cancer treatments involving surgery, radiotherapy, and chemotherapy target the vast majority of cancer cells, but they are only partially effective in eliminating the disease. Failure to eliminate cancer with conventional treatments can lead to recurrence, which usually kills patient. READ MORE