Search for dissertations about: "Immunogenic cell death"
Showing result 1 - 5 of 11 swedish dissertations containing the words Immunogenic cell death.
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1. Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells
Abstract : The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (TH) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. READ MORE
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2. Immunological effects of isolated regional perfusion in malignant melanoma
Abstract : Malignant melanoma patients with metastatic disease confined to the limbs or liver may be treated with hyperthermic isolated regional perfusion with a chemotherapeutic agent, most commonly melphalan. This procedure enables much higher tissue concentrations of the chemotherapeutic agent compared with systemic administration. READ MORE
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3. Dendritic cell responses to apoptotic cells : is there life after death?
Abstract : Dendritic cells (DC) are antigen-presenting cells that are crucial for the induction of immune responses to pathogens and for the maintenance of self-tolerance. DCs efficiently capture and process material from their local environment, including invading pathogens and dying cells of the host, and present the material to the adaptive immune response. READ MORE
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4. Regulation of T cell activation and death by the affinity of TCR for peptide/MHC complexes
Abstract : The aim of this study is to investigate the role of the affinity of peptide:MHC/TCR interaction in the regulation of T cell activation, death and repertoire selection. Three aspects pertinent for our understanding of this issue have been analyzed. READ MORE
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5. Reconstruction of vocal fold scarring with mesenchymal stromal cell therapy
Abstract : Tissue injury/scarring of the vocal folds (VFs) can be caused by various factors including external trauma, cancer treatment or inflammation, leading to damage within the vibrating layers and a decrease in viscoelastic functions. These effects ultimately result in severe voice problems. This condition leads to significant morbidity for patients. READ MORE