Search for dissertations about: "Immunoglobulin gene rearrangement"

Showing result 1 - 5 of 12 swedish dissertations containing the words Immunoglobulin gene rearrangement.

2. 1. Immunoglobulin Gene Analysis in Different B cell Lymphomas : With Focus on Cellular Origin and Antigen Selection

   Author : Mia Thorsélius; Richard Rosenquist Brandell; Christer Sundström; Anders Rosén; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; B cell lymphoma; Immunoglobulin; V gene; somatic hypermutation; antigen selection; quantitative PCR; Genetik; Clinical genetics; Klinisk genetik;

   Abstract : B cell lymphoma (BCL) comprises a biologically and clinically heterogeneous group of tumors deriving from different stages of B cell development. The immunoglobulin (Ig) variable heavy chain (VH) gene rearrangement is unique for each BCL and can be used to reveal cellular origin, to study signs of antigen selection and to quantify tumor cell load. READ MORE

4. 2. Detection of immunoglobulin heavy chain gene rearrangement with PCR for MRD analysis in lymphoproliferative disorders

   Author : Ulf Thunberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Minimal residual disease; Immunoglobulin gene rearrangement; PCR; Leukemia; Lymphoma; Myeloma; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Abstract : Immunoglobulin heavy chain (IGH) gene rearrangement occurs during early B-lymphocyte differentiation, assembling the different IGH gene segments to a functional gene, which can serve as a marker for study of lineage association and detection of Minimal Residual Disease (MRD) in clonal diseases deriving from B-lymphocytes or their early differentiation stages. Use of a molecular marker for the leukemic cells could help improve treatment by monitoring therapeutic efficacy, predicting relapse, and identifying very small amounts of tumour cells contaminating autografts after purging or enrichment of stem cells. READ MORE

5. 3. Immunoglobulin Gene Analysis in Chronic Lymphocytic Leukemia : Characterization of New Prognostic and Biological Subsets

   Author : Gerard Tobin; Richard Rosenquist; Christer Sundström; Anna Laurell; Nicholas Chiorazzi; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; chronic lymphocytic leukemia; immunoglobulin genes; VH3-21; CDR3; P2X7; Genetik; Clinical genetics; Klinisk genetik;

   Abstract : Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can divide chronic lymphocytic leukemia (CLL) into two prognostic subsets, since cases with mutated VH genes display superior survival compared to unmutated cases. Biased VH gene usage has also been reported in CLL which may reflect antigen selection. READ MORE

6. 4. The immunoglobulin genes in an Actinopterygian fish, the Siberian sturgeon (Acipenser baeri)

   Author : Mats Lundqvist; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Immunoglobulin genes; gene organization; transmembrane TM ; comparative immunology; Siberian sturgeon Acipenser baerii ; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Immunology; molekylär immunologi;

   Abstract : Characterization of the immunoglobulin (Ig) light (L) and heavy (H) chain genes from the Siberiansturgeon, Acipenser baeri, revealed an Ig structure simhar to the IgM elass of mammals. The serumforms of the sturgeon Ig are tetrameric and dimeric. READ MORE

7. 5. Reconstitution of the B-cell repertoire following allogeneic bone marrow transplantation

   Author : Ingrid Näsman Björk; Karolinska Institutet; Karolinska Institutet; []
   Keywords : B cell repertoire allogeneic bone marrow transplantation immune reconstitution immunoglobulin genes serum immunoglobulin;

   Abstract : Allogeneic bone marrow transplantation (BMT) is an established therapy for patients with a variety of haematological malignancies. Patients undergoing BMT often suffer from severe infections that can be partly explained by humoral immune deficiency. READ MORE