Search for dissertations about: "In Situ Hybridization methods"

Showing result 1 - 5 of 64 swedish dissertations containing the words In Situ Hybridization methods.

2. 1. Expression and Mutation Analyses of Candidate Cancer Genes In Situ

   Author : Sara Kiflemariam; Tobias Sjöblom; Fredrik Pontén; Mef Nilbert; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; in situ; in situ hybridization; padlock probes; mRNA; tyrosine kinases; tyrosine phosphatases; fusion transcripts;

   Abstract : Cancers display heterogeneity in genetic profiles of the individual cancer cells and in the composition of different malignant and non-malignant cell populations. Such intra-tumor heterogeneity plays a role in treatment response and the emergence of resistance to cancer therapies. READ MORE

4. 2. Advancing DNA-based proximity methods

   Author : Mattias Leino; Ola Söderberg; John Löfblom; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; in situ; proximity dependent intiation of hybridization chain reaction; hybridization chain reaction; Oligonucleotide design; proximity ligation assay; protein interaction; microscopy; purification; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : Cellular functions are governed by intricate chains of interactions between proteins. In order to properly understand cellular biology one must look into, not only protein function, but also its interacting network. READ MORE

5. 3. Trisomies in Hematologic Malignancies

   Author : Kajsa Paulsson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical genetics; Klinisk genetik; cytogenetik; Genetik; cytogenetics; Genetics; leukemia; chromosome aberration; trisomy;

   Abstract : Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.. READ MORE

6. 4. Squamous cell carcinoma of the head and neck, focusing on Epstein-Barr-virus, programmed cell death ligand 1 and serum lipoproteins

   Author : Torben Wilms; Karin Nylander; Xiaolian Gu; Linda Boldrup; Keith Hunter; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oral tongue cancer; squamous cell carcinoma; head and neck; Epstein Barr Virus; PD-L1; lipoprotein; Oncology; onkologi; Oto-Rhino-Laryngology; oto-rhino-laryngologi; Pathology; patologi; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar; immunologi; Immunology;

   Abstract : Background: Squamous cell carcinoma of the head and neck (SCCHN)comprises a large group of tumours including the oral cavity and nasopharyngealarea, and typically affects older males in association with alcohol/tobacco usage.Within the oral cavity, the mobile tongue is the most common site for tumourdevelopment. READ MORE

7. 5. Neuropeptidomics – Methods and Applications

   Author : Karl Sköld; Per E Andrén; Per Svenningsson; Chris Shaw; Uppsala universitet; []
   Keywords : Pharmaceutical pharmacology; mass spectrometry; proteomics; peptidomics; neuropeptide; bioinformatics; Farmaceutisk farmakologi;

   Abstract : The sequencing of genomes has caused a growing demand for functional analysis of gene products. This research field named proteomics is derived from the term proteome, which by analogy to genome is defined as all proteins expressed by a cell or a tissue. READ MORE