Search for dissertations about: "In silico"

Showing result 1 - 5 of 147 swedish dissertations containing the words In silico.

  1. 1. In silico tools in risk assessment of industrial chemicals in general and non-dioxin-like PCBs in particular

    University dissertation from Umeå : Umeå Universitet

    Author : Mia Stenberg; Patrik Andersson; Miriam Jacobs; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; industrial chemicals; in silico tools; molecular descriptors; non-dioxin-like PCBs; partial least-squares PLS ; principal component analysis PCA ; quantitative structure-activity relationship QSAR ; REACH; risk assessment RA ; statistical molecular design; structure-activity relationship SAR ;

    Abstract : Industrial chemicals in European Union produced or imported in volumes above 1 tonne annually, necessitate a registration within REACH. A common problem, concerning these chemicals, is deficient information and lack of data for assessing the hazards posed to human health and the environment. READ MORE

  2. 2. Development of Methods for Assessing Unbound Drug Exposure in the Brain In vivo, in vitro and in silico

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Fridén; Margareta Hammarlund-Udenaes; Ulf Bredberg; Yuichi Sugiyama; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Drug transport; Tissue distribution; Transporters; Pharmacokinetics; PHARMACY Other pharmacy; FARMACI Övrig farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; PHARMACY Pharmaceutical pharmacology; FARMACI Farmaceutisk farmakologi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The blood-brain barrier is formed by tightly joined capillary cells with transporter proteins and acts as to regulate the brain concentration of nutrients as well as many drugs. When developing central nervous system drugs it is necessary to measure the unbound drug concentration in the brain, i.e. the unbound brain exposure. READ MORE

  3. 3. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs a Study Involving in silico, in vitro and in vivo Assessment

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

    Abstract : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. READ MORE

  4. 4. Twin-arginine translocation in Yersinia the substrates and their role in virulence

    University dissertation from Umeå : Umeå University

    Author : Ummehan Avican; Åke Forsberg; Åsa Sjöling; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; Tat; virulence; Tat substrates; SufI; stress response; metabolism; infection; transcriptome analysis; Infectious Diseases; infektionssjukdomar; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Abstract : Pathogenic Yersinia cause a manifold of diseases in humans ranging from mild gastroenteritis (Y. pseudotuberculosis and Y. enterocolitica) to pneumonic and bubonic plague (Y. READ MORE

  5. 5. Extinctions in Ecological Communities direct and indirect effects of perturbation on biodiversity

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Alva Curtsdotter; Bo Ebenman; Peter Münger; Elisa Thébault; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : In the dawning of what may become Earth’s 6th mass extinction the topic of this thesis, understanding extinction processes and what determines the magnitude of species loss, has become only too relevant. The number of known extinctions (~850) during the last centuries translates to extinction rates elevated above the background rate, matching those of previous mass extinction events. READ MORE