Search for dissertations about: "In utero transplantation"

Showing result 1 - 5 of 9 swedish dissertations containing the words In utero transplantation.

  1. 1. Rejection and Immunosuppression at Uterus Transplantation: an experimental study in rodents

    Author : Klaus Groth; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; uterus; transplantation; rejection; cyclosporine A;

    Abstract : Uterus transplantation is developed as a possible treatment for patients with absolute uterine factor infertility. There has been one attempt to transplant a human uterus, which however failed and more basic research is needed before another attempt is performed. READ MORE

  2. 2. Experimental studies of human fetal liver cells : in regard to in utero hematopoietic stem cell transplantation

    Author : Bim Lindton; Karolinska Institutet; Karolinska Institutet; []
    Keywords : In utero transplantation; fetal liver cells; mixed lymphocyte culture; CD3; CD56; HLA class II; parvovirus B 19 capsids; corticosteroids; cytotoxic drugs; colony formation.;

    Abstract : Successful in utero hematopoietic stem cell transplantation represents a potential step forward in the management of patients with severe inherited hematological, metabolic and immunological disorders. Animal data from a number of species have demonstrated evidence of engraftment, but to date the only effective in utero transplantations (IUTx) in humans have been performed in fetuses with severe immunodeficiencies, suggesting that the fetal immune system play a vital role in the success or failure of in utero transplantation. READ MORE

  3. 3. Fetal hematopoietic cells in early gestation : aspects in view of fetal transplantation

    Author : Sverker Ek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Fetal stem cells; fetal liver; fetal hematopoiesis; immunological ontogeny; fetal transplantation; cytokines; CD34 enrichment;

    Abstract : The fetus as a patient is a challenge. There are opportunities for early, sometimes life-saving procedures or there may be advantages in prenatal rather than postnatal intervention. This is the case in fetal hematopoietic cell (FHC) transplantation where conditions caused by a defect in blood cell formation may be life-threatening to the fetus. READ MORE

  4. 4. Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy

    Author : Karina Liuba; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in utero hematopoietic cell transplantation; hematopoietic stem cell; multipotent progenitor; fetal therapy; heterotypic cell fusion;

    Abstract : Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient in hope of correcting the disorder and preventing postnatal permanent organ damage. READ MORE

  5. 5. Molecular and cellular analysis of Lhx2 function in hematopoietic stem cells

    Author : Karin Richter; Leif Carlsson; Andrew Elefanty; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; Lhx2; cell lines; self renewal; SCF; IL-6; chronic myeloproliferative disorder; global gene expression analysis; Molecular biology; Molekylärbiologi;

    Abstract : The formation of blood, hematopoiesis, is a dynamic process originating from a small number of hematopoietic stem cells (HSCs). To sustain hematopoiesis throughout life HSCs have the unique capacity to differentiate into all mature hematopoietic lineages as well as generating more HSCs by a mechanism referred to as self-renewal. READ MORE