Search for dissertations about: "In vitro reprogramming"

Showing result 11 - 15 of 36 swedish dissertations containing the words In vitro reprogramming.

  2. 11. Mechanisms Underlying the Specification of Definitive Hematopoiesis

    Author : Rita Alves; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GATA2; mitotic bookmarking; HSC; transcription factors; reprogramming;

    Abstract : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. READ MORE

  4. 12. Deciphering microglia plasticity in glioma

    Author : Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. READ MORE

  5. 13. Impact of targeting MYC in metabolic reprogramming and differentiation of cancer

    Author : Lourdes Sainero Alcolado; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alterations in several metabolic pathways due to increased energy and biomass demand, as consequence of the uncontrolled proliferation of cancer cells, is known as metabolic reprogramming. Mutations in tumor suppressor genes and oncogenes that initiate cancer development, are responsible directly and indirectly of the changes in major cellular energy production processes, including glycolysis, glutaminolysis, and lipid metabolism. READ MORE

  6. 14. Coiled coil cytoskeleton in cell architecture and osmotic stress response in Streptomyces

    Author : Katsuya Fuchino; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Coiled coil protein; Streptomyces coelicolor; polar growth; osmotic-stress response; turgor;

    Abstract : Coiled coil proteins emerge as important determinants of bacterial cellular organization. Several such proteins display properties characteristic to metazoan intermediate filament (IF) proteins, and are therefore designated bacterial IF-like proteins. READ MORE

  7. 15. Altered cell metabolism and migration in nasopharyngeal carcinoma

    Author : Shixing Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer, originating from the nasopharynx. The etiology of NPC is considered a complex interaction between Epstein–Barr virus (EBV) infection, genetic susceptibility, environmental factors, and lifestyle factors. NPC has the highest metastasis rate among all head and neck cancers. READ MORE