Search for dissertations about: "In vitro reprogramming"

Showing result 21 - 25 of 36 swedish dissertations containing the words In vitro reprogramming.

  2. 21. Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts

    Author : Karthikeyan Devaraju; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adult neurogenesis; stroke; neural stem cells; Lnk; ependymal cells; FoxJ1; cortical reprogramming;

    Abstract : Stroke is a major cause of death and disability around the world. Stroke leads to loss of neurons and also other cells in the brain due to lack of blood supply. Currently no therapies are available to treat stroke-related disability. It has been shown that stroke leads to increased neurogenesis, birth of new neurons, within the brain. READ MORE

  4. 22. Hypoxia-inducible factor-1 (HIF-1) in pancreatic cancer cell aggressiveness and therapeutic resistance and the potential role for pancreatic endocrine cells in islet transplantation

    Author : Xiaohui Jia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic functions in various tissues, including both normal and malignant. It is known that a heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1) mainly mediates this critical adaptation. READ MORE

  5. 23. Focus on fibroblasts : development, plasticity, and therapeutic challenges in the cardiac fibroblast lineage

    Author : Giorgia Palano; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiac fibroblasts (CFs) are cells of mesenchymal origin and represent a heterogeneous population in the mammalian heart. They secrete extracellular matrix (ECM) molecules providing structural support during heart development and homeostasis. In response to injury, CFs are activated and undergo phenotypic conversion to myofibroblasts (myoFBs). READ MORE

  6. 24. Implementing new genomic tools to study ventral midbrain development and injury response in the newt Pleurodeles waltl

    Author : Zeyu Yao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammals have a poor ability to regenerate organs or tissues. In particular, brain neurons do not regenerate after damage. A good example of this limitation is the irreversible degeneration of midbrain dopaminergic neurons in Parkinson’s disease (PD). Several strategies are being developed to treat PD. READ MORE

  7. 25. 24s-Hydroxycholesterol : studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration

    Author : Marjan Shafaati; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC). This structural modification allows 24S-OHC to traverse the blood brain barrier and this pathway is the major one for elimination of cholesterol from the mammalian brain. READ MORE