Search for dissertations about: "In vitro reprogramming"

Showing result 6 - 10 of 36 swedish dissertations containing the words In vitro reprogramming.

  2. 6. Development and Applications of in vitro Models to Study Human Brain Evolution and Disease

    Author : Daniela Grassi; Molekylär neurogenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural reprogramming; Neural differentiation; Brain development; Huntington s disease; Induced Neuron; Neural Progenitor Cell; Brain evolution;

    Abstract : Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. READ MORE

  4. 7. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells

    Author : Alexandra Gabriela Barros Ferreira; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell Reprogramming; Cancer cells; Tumor Antigen-presenting Cells; immunotherapy;

    Abstract : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. READ MORE

  5. 8. Regulatory properties of dendritic cells and B cells in adaptive immunity

    Author : Bengt Johansson Lindbom; Adaptivt immunförsvar; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; transplantation; Immunologi; serologi; Immunology; Cellular differentiation; Cytokines; Dendritic cells; B lymphocytes; T lymphocytes;

    Abstract : This thesis is based upon four original papers in which human dendritic cells (DCs) and B cells have been analyzed in terms of how they influence the character of adaptive immune responses. DCs isolated from human tonsils were found to possess a capacity to directly regulate proliferation, isotype switching, and antibody production in B cells. READ MORE

  6. 9. Generating GABAergic interneurons through reprogramming and differentiation strategies : English

    Author : Andreas Bruzelius; Regenerativ neurofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; interneurons; neuronal reprogramming; glial progenitor cells; neuronal differentiation; human embryonic stem cells; induced neurons; somatostatin; parvalbumin;

    Abstract : In recent years reprogramming techniques, differentiation protocols, and sequencing analysis have opened a field for generating and studying human-derived neurons with greater potential than ever before. This has generated a large number of studies with the goal of deriving bona fide neurons. READ MORE

  7. 10. Neural Stem Cells - interaction with the brain and prospects for cell replacement therapy for Stroke

    Author : Emanuela Monni; Neural stamcellsbiologi och terapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural stem cells; human; fetus; cortex; striatum; stroke; transplantation; inflammation; fusion; reprogramming; chimera; heterokaryon;

    Abstract : Stroke is an acute neurological condition and the leading cause of disability in adult humans. Treatments for efficient recovery are not available. The most common form of stroke results from the occlusion of the middle cerebral artery, which causes loss of brain parenchyma and many types of neurons as well as astrocytes and oligodendrocytes. READ MORE