Search for dissertations about: "In vivo hybridisation"

Showing result 1 - 5 of 17 swedish dissertations containing the words In vivo hybridisation.

  2. 1. Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology

    Author : Gábor Lendvai; Mats Bergström; Sergio Estrada; Barbro Eriksson; Raymond Josephsson; Bertrand Tavitian; Uppsala universitet; []
    Keywords : Molecular medicine; Gene expression; Antisense oligonucleotides; Positron emission tomography; In vivo hybridisation; In vivo biodistribution; Chromogranin-A; 68Ga; RT-PCR; Scavenger receptors; Molekylärmedicin;

    Abstract : Antisense oligonucleotides (ODN) may interfere in gene expression on the basis of hybridising to its complementary messenger RNA (mRNA) sequence in the cell thereby preventing the synthesis of the peptide. Therefore, these ODNs may be potential drugs to treat human diseases by “knocking down” the expression of responsible genes or correcting the maturation process of mRNA in the field called antisense therapy. READ MORE

  4. 2. Short-chain retinol dehydrogenases/reductases : Involvement in retinoid metabolism and expression in embryonic and adult mouse

    Author : Paulina Tuvendal; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; -; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : Retinoids are needed in the embryo to ensure proper development and in the adult forvision, maintenance of epithelia and sperm production. Retinol is oxidised within the cell generating retinal and, irreversibly, retinoic acid. READ MORE

  5. 3. Genome characterisation and mobility investigation in trypanosomes

    Author : Carole Branche; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma brucei - Trypanosoma cruzi - karyotype - genome organisation -flageflum mobility - RNAi - functional studies.;

    Abstract : Trypanosomes are uni-flagellated protozoa responsible for some of the most debilitating human infections such as Chagas disease (Trypanosoma cruzi) and sleeping sickness (Trypanosoma brucei). Unravelling their genome organisation and their biology would improve our basic knowledge and could contribute to find new drug target specific to the species. READ MORE

  6. 4. The role of substance P in respiratory control in the newborn : effects of morphine and nicotine

    Author : Jonas Berner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : We breathe in order to maintain oxygen, carbon dioxide and pH levels within the physiological range in response to the metabolic demands of the body. To achieve this, the respiratory control system is dependent on input from peripheral and/ central chemosensitive areas and on participation of different neuromodulator systems. READ MORE

  7. 5. The CHD chromatin remodeling factors in schizosaccharomyces pombe

    Author : Julian Walfridsson; Karl Ekwall; Pernilla Bjerling; Stefan Björklund; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Regulation of chromatin structure is essential in a wide variety of processes including transcriptional regulation, recombination, replication, chromosome segregation, development and differentiation. The enzymes that are central in regulating chromatin structure can be classified into two major groups. READ MORE