Search for dissertations about: "Individual dosage"

Showing result 16 - 20 of 35 swedish dissertations containing the words Individual dosage.

  2. 16. Suicide : a pharmacoepidemiological database study in the region Friuli Venezia Giulia, Italy

    Author : Giulio Castelpietra; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aims: The objective of this thesis is to examine the relationship between suicide and health care in Italy’s Friuli Venezia Giulia (FVG) region. First, it explores the correlation between suicide rates and antidepressant sales. READ MORE

  4. 17. Genetic and metabolic studies towards personalized conditioning regimen prior to stem cell transplantation

    Author : Ibrahim El-Serafi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and non- malignant diseases. The busulphan (Bu)/cyclophosphamide (Cy) combination is one of the most common conditioning regimens given prior to HSCT. READ MORE

  5. 18. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

    Author : Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

    Abstract : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. READ MORE

  6. 19. Screening, Targeting, Tailoring, and Implementation in Primary Health Care : An integrated physical therapy and behavioural medicine approach to persons with persistent musculoskeletal pain

    Author : Maria Sandborgh; Eva Denison; Per Lindberg; Christina Opava; Uppsala universitet; []
    Keywords : Caring sciences; physical therapy; behavioural medicine; screening; chronic pain; primary health care; Vårdvetenskap;

    Abstract : This thesis deals with a behavioural medicine approach to the management of patients with persistent musculoskeletal pain in primary health care physical therapy. The main aims of the thesis were; to develop, and evaluate the psychometric properties of, a screening instrument for risk of disability and; to evaluate the implementation and effects of a targeted and tailored treatment. READ MORE

  7. 20. Methodological Studies on Covariate Model Building in Population Pharmacokinetic-Pharmacodynamic Analysis

    Author : Ulrika Wählby; Thomas Ludden; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Population pharmacokinetic (PK) – pharmacodynamic (PD) modelling, using nonlinear mixed effects models, is increasingly being applied to obtain PK-PD information in drug development. Covariate modelling, the establishment of relationships between model parameters and patient characteristics, is undertaken to explain PK-PD variability and facilitate dose adjustment decisions, and is consequently an important objective of population PK-PD. READ MORE