Search for dissertations about: "Influenza"

Showing result 6 - 10 of 155 swedish dissertations containing the word Influenza.

2. 6. Avian Influenza Virus : Deciphering receptor interactions and their role in interspecies transmission

   Author : Per Eriksson; Patrik Ellström; Björn Olsen; Josef D. Järhult; Åke Lundkvist; Jonas Waldenström; Hans-Dieter Klenk; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; birds; glycobiology; glycovirology; host range; mixing vessel; virus attachment; Medical Virology; Medicinsk virologi;

   Abstract : Influenza A virus (IAV) annually infects approximately 5–15 % of the human population, causing ~500,000 deaths globally. Novel IAVs have emerged and spread pandemically in the human population, but have over time established endemic circulation with reduced pathogenicity causing seasonal influenza. The natural reservoir of IAVs is wild waterfowl. READ MORE

4. 7. Tamiflu® - Use It and Lose It?

   Author : Josef D. Järhult; Björn Olsen; Hanna Söderström; Jonas Waldenström; Robert G. Webster; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; oseltamivir; Tamiflu; resistance development; H274Y; environment; pharmaceuticals; mallard; dabbling duck; avian influenza; influensa; resistensutveckling; miljö; läkemedel; gräsand; Infektionssjukdomar; Infectious Diseases;

   Abstract : Influenza A viruses cause seasonal and pandemic outbreaks that range from mild infections to the disastrous Spanish Flu. Resistance to neuraminidase inhibitors (NAIs) is a growing problem as these drugs constitute a vital part of treatment strategies and pandemic preparedness plans worldwide. Oseltamivir (Tamiflu®) is the mostly used NAI. READ MORE

5. 8. Resistance to neuraminidase inhibitors in influenza A virus isolated from mallards

   Author : Goran Orozovic; Björn Olsen; Johan Lennerstrand; Sigvard Olofsson; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; influenza; mallards; neuraminidase; PCR; sequencing; mutation; oseltamivir; zanamivir; resistance; NAI; antivirals; pandemic; Virology; Virologi; Molecular biology; Molekylärbiologi; Bioinformatics; Bioinformatik; Zoonotisk ekologi; Zoonotic Ecology; Virology; Virologi; Biokemi; Biochemistry;

   Abstract : Influenza A virus belongs to the Orothomyxoviridae family of viruses and is one of the most common pathogens that cause infections of the respiratory tract. The aim of this thesis was to investigate if neuraminidase inhibitor (NAI) Tamiflu® (oseltamivir, OC) and Relenza® (zanamivir, ZA) - related resistance mutations exist in the neuraminidase (NA) gene of viruses collected from wild birds. READ MORE

6. 9. Epidemiology of viral respiratory infections with focus on in-hospital influenza transmission

   Author : Martina Sansone; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; rhinovirus; infection-control; hospital outbreak; nosocomial; phylogeny; polymerase chain reaction; viral transmission; whole-genome sequencing; system dynamics;

   Abstract : Human Rhinoviruses (HRV) and influenza viruses are respiratory pathogens which represent a major global disease burden. Healthcare-associated infections (HCAI) are increasingly recognized as a public health concern, but limited data has been published on the characteristics and epidemiology of HCAI caused by respiratory viruses. READ MORE

7. 10. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

   Author : Ajibola Omokanye; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

   Abstract : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. READ MORE