Search for dissertations about: "Ingrid Pontén"

Found 1 swedish dissertation containing the words Ingrid Pontén.

2. 1. Studies on oligonucleotide adducts formed from 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[A]pyrene stereoisomers

   Author : Ingrid Pontén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The widespread environmental pollutant benzo[a]pyrene (BP), is formed from incomplete combustion of fossil fuels and is mutagenic and carcinogenic after metabolic activation to bay-region diol epoxides and subsequent covalent binding to DNA. The metabolic activation pathway to diol epoxides is via BP-7,8-oxide and BP-7,8-dihydrodiol to yield preferentially 7R,8S-dihydroxy-9S,lOR-epoxy-7,8,9,10-tetrahydrobenzo[a]py- rene [(+)-anti-BPDE] and to lesser extents, 7R,8S-dihydroxy-9R,lOS-epoxy-BP [(-)-syn-BPDE], 7S,8R- dihydroxy-9S,lOR-epoxy-BP [(+)-syn-BPDE] and 7S,8R-dihydroxy-9R,lOS-epoxy-BP [(-)-anti-BPDE]. READ MORE