Search for dissertations about: "Innervation zone"

Found 4 swedish dissertations containing the words Innervation zone.

  2. 1. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

    Author : Elin Andersson; Neurobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

    Abstract : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. READ MORE

  4. 2. Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins

    Author : Julianna M V Kele-Olovsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The main pathology is characterized by progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra leading to loss of striatal dopamine innervation. The knowledge about the fundamental mechanisms behind the degenerative process has been limited. READ MORE

  5. 3. Dynamic mechanical allodynia in peripheral neuropathic pain : psychological observations

    Author : Monika Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dynamic mechanical allodynia; Brush-evoked allodynia; Brush-evoked pain; Neuropathic pain; Pain descriptors; Repeatability; Human pain model; Capsaicin; Psychophysical observations;

    Abstract : Introduction and aim: Pain due to a light moving mechanical stimulus, dynamic mechanical allodynia, is a protruding symptom/sign in subgroups of patients with peripheral neuropathic pain and frequently as troublesome as spontaneous ongoing pain. The objective of this thesis was to survey psychophysical details of dynamic mechanical allodynia using a novel semi-quantitative method. READ MORE

  6. 4. Neuropharmacological studies of Parkinson's disease with some emphasis on serotonin transmission

    Author : Xiaoqun Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by hypokinesia, rigidity, tremor, gait disturbances and depression. There is an accumulative of protein aggregates, Lewy bodies, which appear to begin in the brainstem and progress caudorostrally. READ MORE