Search for dissertations about: "Institutionen För Kemi Och Biomedicin kob Linnéuniversitetet"

Showing result 1 - 5 of 35 swedish dissertations containing the words Institutionen För Kemi Och Biomedicin kob Linnéuniversitetet.

2. 1. Progress of Weak Affinity Chromatography as a Tool in Drug Development

   Author : Elinor Meiby; Sten Ohlson; Manfred Raida; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; weak affinity chromatography; fragment based drug discovery; fragment screening; thrombin; trypsin; cyclin G-associated kinase; Hsp90; Pin1; cyclooxygenase; lipodisks; Biokemi; Biochemistry;

   Abstract : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. READ MORE

4. 2. Design and engineering of human transferrin receptor 1 and its binding proteins

   Author : Dick J. Sjöström; Sinisa Bjelic; John Löfblom; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transferrin receptor; Machupo virus; protein engineering; Rosetta; flow cytometry; directed evolution; Biomedical Sciences; Biomedicinsk vetenskap;

   Abstract : The human transferrin receptor 1 (TfR) is central in maintaining adequate cellular iron levels with the iron carrier proteins transferrin (Tf) and ferritin (Ft). Known to bind TfR is also HFE, another iron regulatory protein, competing with Tf for receptor binding. READ MORE

5. 3. QCM-based sensing using biological and biomimetic interfaces

   Author : Louise Elmlund; Ian Nicholls; Teodor Aastrup; Jesper Wiklander; Kristina Nilsson-Ekdahl; Håkan Andersson; Susanne Wikman; Alessandra Maria Bossi; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Quartz crystal microbalance; molecularly imprinted polymers; phage display; interactions; artificial receptors; recognition; selectivity; Kemi; Chemistry;

   Abstract : The objective of this thesis was to explore novel approaches for studying molecular recognition at biological and biomimetic surfaces using the quartz crystal microbalance (QCM) biosensor technique. The first two papers focused on the synthesis and study of biotin selective polymer films prepared using the molecularly imprinted polymer (MIP) technique. READ MORE

6. 4. Novel strategies for C-C/X bond formation

   Author : Prasad Anaspure; Ian A. Nicholls; Suppan Kathiravan; Jesper G. Wiklander; Subramanian Suriyanarayanan; Yannick Landais; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; annulation; C-H activation; heterocycles; heterogeneous catalysis; homogeneous catalysis; lab-on-a-chip; Suzuki cross-coupling; Organic Chemistry; Organisk kemi;

   Abstract : The formation of C-C/X bonds is essential for the manufacture of a broad range of chemicals and materials used in areas critical for maintaining quality of life in modern society, e.g. pharmaceuticals, agrochemicals and polymers, and for aspects of research in organic chemistry. READ MORE

7. 5. New Strategies for Preparing Polymers with Hierarchical Architectures

   Author : Natacha Ndizeye; Ian A. Nicholls; Alessandra Maria Bossi; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Liquid crystalline media; molecularly imprinted polymers; non-ionic deep eutectic solvents; quartz crystal microbalance; Organic Chemistry; Organisk kemi;

   Abstract : The objective of this thesis was to explore novel approaches for controlling morphologies and molecular recognition behaviour of polymers and to use these strategies in conjunction with the molecular imprinting technique in order to either enhance polymer performance in quartz crystal microbalance (QCM) sensor applications, or as an alternative to conventional solvents of polymerization. In Papers I and II, the use of liquid crystalline media in the synthesis of molecularly imprinted polymers was demonstrated. READ MORE