Search for dissertations about: "Institutionen För Matematiska Vetenskaper Göteborgs Universitet"

Showing result 1 - 5 of 222 swedish dissertations containing the words Institutionen För Matematiska Vetenskaper Göteborgs Universitet.

2. 1. Modelling of drug-effect on time-varying biomarkers

   Author : Felix Held; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cortisol; TNFα; hierarchical modelling; turnover model; pharmacokinetic pharmacodynamic modelling; cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling;

   Abstract : Model-based quantification of drug effect is an efficient tool during pre-clinical and clinical phases of drug trials. Mathematical modelling can lead to improved understanding of the underlying biological mechanisms, help in finding shortcomings of experimental design and suggest improvements, or be an effective tool in simulation-based analyses. READ MORE

4. 2. Data-driven modeling of combination therapy in oncology

   Author : Tim Cardilin; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling; Nonlinear Mixed-Effects Models;

   Abstract : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. READ MORE

5. 3. Spatial analysis and modeling of nerve fiber patterns

   Author : Claes Andersson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; hierarchical models; Bayesian estimation; epidermal nerve fibers; cluster processes; spatial point processes; diabetic neuropathy; Bayesian field theory; Diabetic neuropathies; Multilevel models Statistics ; Institutionen för matematiska vetenskaper. Tillämpad matematik och statistik.; CTH;

   Abstract : Diabetic neuropathy is a condition associated with diabetes affecting the epidermal nerve fibers (ENFs). This thesis presents analysis methods and models for ENF data, with two main puroposes: to find early signs of diabetic neuropathy and to characterize how this condition changes the nerve fiber structure. READ MORE

6. 4. The Dirac Equation: Numerical and Asymptotic Analysis

   Author : Hasan Almanasreh; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dirac operator; eigenvalue problem; finite element method; spurious eigenvalues; Petrov-Galerkin; cubic Hermite basis functions; stability parameter; meshfree method; $hp$-cloud; intrinsic enrichment; G-convergence; $ Gamma$-convergence; scattering theory; identification; wave operator; stationary approach; Dirac operator;

   Abstract : The thesis consists of three parts, although each part belongs to a specific subject area in mathematics, they are considered as subfields of the perturbation theory. The main objective of the presented work is the study of the Dirac operator; the first part concerns the treatment of the spurious eigenvalues in the computation of the discrete spectrum. READ MORE

7. 5. The Dirac Operator; From Numerics to the Theory of G-convergence

   Author : Hasan Almanasreh; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Dirac operator; spuriousity; cubic Hermitian; stability parameter; G-convergence; ¡-convergence; spectral measure; quadratic form; stability parameter;

   Abstract : We consider two main issues concerning the Dirac operator, the first is widely known as the appearance of spurious eigenvalues within the spectrum. The second is the study of the asymptotic behavior of the eigenvalues for a family of Dirac operators with oscillatory potential added to the Coulomb-Dirac Hamiltonian. READ MORE