Search for dissertations about: "Insulin secretion"
Showing result 11 - 15 of 402 swedish dissertations containing the words Insulin secretion.
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11. Pathophysiology and treatment of defective insulin secretion in diabetes
Abstract : Defective insulin secretion is a central feature in diabetes mellitus and results from reduced pancreatic beta-cell mass as well as aberrant beta-cell function. The pathophysiology of diabetes is incompletely known, but a strong hereditary component is suggested. READ MORE
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12. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects
Abstract : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. READ MORE
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13. Ion channel control of phasic insulin secretion
Abstract : Glucose-stimulated insulin secretion exhibits a biphasic pattern. The mechanism underling biphasic insulin secretion is not fully understood, but consensus exists that an elevation in [Ca2+]i is required for both first- and second-phase insulin secretion. READ MORE
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14. Mechanisms of defective insulin secretion in type 2 diabetes
Abstract : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. READ MORE
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15. Oscillatory Signaling and Insulin Secretion from Single ß-cells
Abstract : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. READ MORE