Search for dissertations about: "Insulin-like Growth Factor"

Showing result 1 - 5 of 213 swedish dissertations containing the words Insulin-like Growth Factor.

  2. 1. Insulin-like Growth Factor System: functional role and regulation in carcinomas

    Author : Ann Rosendahl; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancerology; oncology; Cytology; PTEN; Transforming Growth Factor-beta; Insulin-like Growth Factor; Renal Cell Carcinoma; Cytologi; onkologi; cancer; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : The insulin-like growth factor (IGF) system demonstrates numerous actions during neoplastic growth and is therefore an interesting target with potential clinical implications. While numerous studies have established important roles of the IGF system in regulating cellular growth and survival of several tumor forms, very limited reports exist regarding its role in renal cell carcinoma (RCC). READ MORE

  4. 2. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

    Author : Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Insulin-like growth factor;

    Abstract : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. READ MORE

  5. 3. Insulin-like Growth Factor-I (IGF-I) and Interleukin-6 (IL-6) regulate body fat

    Author : Kristina Wallenius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; insulin-like growth factor I IGF-I ; interleukin-6 IL-6 ; growth hormone GH ; GH releasing factor GHRF ; GH secretagogue GHS ; receptor; leptin; insulin; glucose; intracerebroventricular ICV ; dual-energy X-ray absorptiometry DXA ; indirect calorimetry.;

    Abstract : The aim of this thesis was to investigate the role of insulin-like growth factor-I (IGF-I) and interleukin-6 (IL-6) in the regulation of metabolism and body fat mass. Circulating IGF-I is mainly liver derived, while a large part of circulating IL-6 is produced by adipose tissue. READ MORE

  6. 4. Targeting insulin-like growth factor-1 receptor in cancer

    Author : Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

    Abstract : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. READ MORE

  7. 5. Prolactin and growth hormone in breast cancer. Studies of human breast cancer and transgenic tumor models

    Author : Maria Gebre-Medhin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prolactin; growth hormone; breast cancer; transgenic mice; estrogen receptor; insulin-like growth factor; insulin-like growth factor-I receptor;

    Abstract : Prolactin (PRL) and growth hormone (GH) are two related pituitary peptide hormones of importance during normal mammary gland development. Furthermore, their involvement in development and growth of malignant mammary tumors has been suggested by several investigators. READ MORE