Search for dissertations about: "Insulin"
Showing result 16 - 20 of 1522 swedish dissertations containing the word Insulin.
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16. Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes
Abstract : Obesity and specifically central obesity is related to insulin resistance, type 2 diabetes and other components of the so-called metabolic syndrome. The aim of this study was to elucidate the interplay between hormones, nutrients and adipose depots in normal and insulin-resistant fat cell metabolism. READ MORE
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17. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon
Abstract : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. READ MORE
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18. Mechanisms of insulin exocytosis and release
Abstract : Endocrine cells as well as neurons release their hormones and transmitters by regulated exocytosis. In the pancreatic B-cell, stimuli like glucose initiate biochemical and electrical processes that culminate in influx of Ca2+, which then triggers exocytosis of insulin-containing granules. READ MORE
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19. Insulin resistance in skeletal muscle. With special reference to interstitial insulin and glycerol
Abstract : Insulin resistance is a central feature of type 2 diabetes and obesity and is associated with cardiovascular disease. In insulin-resistant muscle, the insulin-mediated glucose uptake is decreased.The delivery of insulin to the interstitial fluid of human skeletal muscle has previously not been investigated. READ MORE
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20. Regulation of insulin signaling and its developmental and functional roles on peptidergic neurons in the Drosophila central nervous system
Abstract : In Drosophila, eight insulin-like peptides (DILP1-8) are produced and secreted in different locations. They regulate many aspects of development and physiology, such as organism growth, metabolic homeostasis, reproduction, stress resistance and life span. READ MORE