Search for dissertations about: "Intact Glycoproteins"

Showing result 1 - 5 of 11 swedish dissertations containing the words Intact Glycoproteins.

  1. 1. Development and application of alternative methods for profiling proteins N-glycosylation

    University dissertation from Stockholm : Department of Environmental Science and Analytical Chemistry, Stockholm University

    Author : Alessandro Quaranta; Stockholms universitet.; [2019]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; N-glycosylation; Glycomics; Glycosylation Biomarkers; Intact Glycoproteins; Glycoform Quantification; Mass Spectrometry; Ion Mobility Spectrometry; MALDI-MS; Paper Spray Ionization; Microfluidics; Magnetic Beads; Immunoaffinity Purification; Nanobodies; Analytical Chemistry; analytisk kemi;

    Abstract : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. READ MORE

  2. 2. Mucins in normal and diseased airways

    University dissertation from Stockholm : Department of Environmental Science and Analytical Chemistry, Stockholm University

    Author : Hans Hovenberg; Lund University.; Lunds universitet.; [1996]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Respiratory system; Submucosal glands; Goblet cells; Organ culture; Respiratory tract; Mucins; Mucus glycoproteins; Andningsorganen;

    Abstract : Mucus glycoproteins (mucins) are the principal constituents of respiratory secretions in health and disease. The increased 'acidity' of mucin producing cells in the bronchitic airways is not reflected in a change of negative charge of bronchitic mucins. READ MORE

  3. 3. Molecular basis for galectin-ligand interactions : Design, synthesis and analysis of ligands

    University dissertation from Lund University, Faculty of Science, Department of Chemistry, Centre for Analysis and Synthesis

    Author : Kristoffer Peterson; Lund University.; Lunds universitet.; [2018-02]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectin; Structure-based design; Thiodigalactoside; Huisgen 1; 3-dipolar cycloaddition; Protein-ligand binding interactions;

    Abstract : Galectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. READ MORE

  4. 4. Laminin G Domains, their Receptors, and Activation of Intracellular Pathways

    University dissertation from Cell and Organism Biology Lund University Sölvegatan 35 SE-22362 Lund

    Author : Hao Yu; Lund University.; Lunds universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; cell-matrix interaction; signaling; receptor; Basement membrane; laminin;

    Abstract : Basement membranes are sheet like structures underlying epithelial, endothelial, adipocytes, muscle and peripheral nerve cells. Laminins are an important family of basement membrane proteins implicated in various biological functions through their interactions with cell surface receptors. Laminins are trimers composed of a, b and g chains. READ MORE

  5. 5. Studies of hepatitis C virus envelope proteins : Interaction with host cells and as targets for the humoral response

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Aster Beyene; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatitis C virus; Envelope protein 1 and 2 E1 and E2 ; humoral response; VSV pseudotype.;

    Abstract : Hepatitis C virus (HCV) is a major cause of chronic hepatitis infection worldwide. It leads to chronic infection in over 80% in infected patients and may result in liver cirrhosis, hepatocellular carcinoma and autoimmune disorders. READ MORE