Search for dissertations about: "Integrin"

Showing result 16 - 20 of 188 swedish dissertations containing the word Integrin.

  2. 16. Studies on chondrocyte integrins and mechanical signaling

    Author : Karin Holmvall; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; teratology; Development biology; collagen; mechnaical stimulation; cartilage; development; chondrocyte; integrin; ontogeny; embryology human ; Utvecklingsbiologi; teratologi; embryologi människa ;

    Abstract : Integrins are a family of cell surface receptors known to bind matrix proteins and to mediate signals such as mechanical signals between the cell and the surrounding matrix. We have studied integrins that are expressed by chondrocytes, with specific focus on the integrins that interact with the cartilage matrix protein collagen type II. READ MORE

  4. 17. Collagen-binding integrin α2β1 activity in vivo and in vitro : Effects of platelet-derived growth factor-BB

    Author : Karina Åhlén; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin α2β1; PDGF-BB; fibroblast; interstitial fluid pressure; cytoskeletal interaction; phosphatidylinositol 3-kinase; [Ca2 ]i; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : The expression of integrins by two cell clones from a rat colon carcinoma was investigated. Cloned cells that gave rise to regressive tumors, but not cells that gave rise to progressive, lethal, tumors, adhered to interstitial collagens through the integrin α2β1, although both cell types expressed it. READ MORE

  5. 18. Adhesion-dependent mechanisms regulating mitosis

    Author : Deepesh Kumar Gupta; Staffan Johansson; Kaisa Haglund; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytokinesis; Centrosome; Septin; Abscission; Mitosis; Integrin; Adhesion; Binucleation; Biokemi; Biochemistry;

    Abstract : Integrin-mediated cell adhesion is required for normal cell cycle progression during G1-S transition and for the completion of cytokinesis. Cancer cells have ability to grow anchorage-independently, but the underlying mechanisms and the functional significance for cancer development are unclear. READ MORE

  6. 19. Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth

    Author : Daniel Öhlund; Malin Sund; Peter Naredi; Matthias Löhr; Umeå universitet; []
    Keywords : Pancreatic cancer; tumor marker; basement membrane; type IV collagen; type XVIII collagen; matrix metalloproteinase; integrin; autocrine loop; tumor stroma; kirurgi; Surgery;

    Abstract : Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. READ MORE

  7. 20. In vitro wound healing characteristics of amelogenins

    Author : Sofia Almqvist; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amelogenins; extracellular matrix; cell culture; macrophage; fibroblast; endothelial cell; integrin; cytokine; inflammation; wound healing tissue repair;

    Abstract : Wound healing involves the co-ordinated actions of several cell types, soluble cell mediators and extracellular matrix (ECM). This research project intended to investigate the role of certain ECM proteins in different processes during tissue repair by studying the interaction between dermal cells and ECM. READ MORE