Search for dissertations about: "Integron"

Showing result 1 - 5 of 16 swedish dissertations containing the word Integron.

  2. 1. Mechanisms and DNA Specificity in Site-specific Recombination of Integron Cassettes

    Author : Carolina Johansson; Lars Sundström; Dan Andersson; Didier Mazel; Uppsala universitet; []
    Keywords : Microbiology; lateral gene transfer; site-specific recombination; tyrosine recombinase; integron; single-stranded; DNA hairpin; Mikrobiologi; farmaceutisk mikrobiologi; Pharmaceutical Microbiology;

    Abstract : Bacterial resistance to antibiotics has become a serious problem. This is due to the remarkable ability of bacteria to respond and rapidly adapt to environmental changes. Integrons are elements with the capacity for gene capture by an integron-encoded site-specific recombinase called IntI. READ MORE

  4. 2. Identification of novel antibiotic resistance genes through the exploration of mobile genetic elements

    Author : Mohammad Razavi; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environment; Metagenomics; Antibiotic resistance; Mobile genetic elements; Insertion sequences; Integron; Resistome; Next-generation sequencing;

    Abstract : Backgrounds and aims: The evolution of multi-resistant pathogens is seriously threatening our ability to provide modern healthcare. Many of the mobile resistance factors in clinics appear to originate from environmental bacteria. READ MORE

  5. 3. Computational Modelling of Ligand Complexes with G-Protein Coupled Receptors, Ion Channels and Enzymes

    Author : Lars Boukharta; Johan Åqvist; Christopher A. Reynolds; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; computer simulations; molecular dynamics; ligand binding; free energy perturbation; linear interaction energy; binding free energy; homology modelling; structure prediction; alanine scanning; site-directed mutagenesis; hERG; GPCR; neuropeptide Y; HIV-1 reverse transcriptase; integron integrase; Molecular Biotechnology; Molekylär bioteknik;

    Abstract : Accurate predictions of binding free energies from computer simulations are an invaluable resource for understanding biochemical processes and drug action. The primary aim of the work described in the thesis was to predict and understand ligand binding to several proteins of major pharmaceutical importance using computational methods. READ MORE

  6. 4. Mechanisms and DNA-specificity in site-specific recombination of integron cassettes

    Author : Carolina Johansson; Uppsala universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  7. 5. Statistical modelling and analyses of DNA sequence data with applications to metagenomics

    Author : Mariana Buongermino Pereira; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; generalised hidden Markov models; gene abundance data; metagenomics; statistical modelling; bioinformatics; normalisation; DNA sequence data; bioinformatics;

    Abstract : Microorganisms are organised in complex communities and are ubiquitous in all ecosystems, including natural environments and inside the human gut. Metagenomics, which is the direct sequencing of DNA from a sample, enables studying the collective genomes of the organisms that are there present. READ MORE