Search for dissertations about: "Interferon Type I"

Showing result 16 - 20 of 97 swedish dissertations containing the words Interferon Type I.

  2. 16. The activation and regulation of plasmacytoid dendritic cells in SLE : and possible therapeutic interventions

    Author : Karin Hjorton; Lars Rönnblom; Maija-Leena Eloranta; Hans Carlsten; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; pDCs; NK cells; interferon; autoantibodies; immune complex; hydroxychloroquine; IRAK4 inhibition;

    Abstract : Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the presence of anti-nuclear antibodies and the formation of nucleic acid containing immune complexes (ICs), which can cause organ damage by deposition in tissues. ICs strongly trigger the plasmacytoid dendritic cells (pDCs) to produce interferon (IFN)-α, which potently activates the immune system. READ MORE

  4. 17. Sjögren's syndrome: epidemiological risk factors and biomarkers

    Author : Peter Olsson; Internmedicin - epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sjögren syndrome; cytokine; Interferon Type I; Cigarette smoking;

    Abstract : Primary Sjögren’s syndrome (pSS) is an autoimmune disease, primarliy affecting women, characterised by inflammation and destruction of exocrine glands with a prevalence of 0.01-0.09%. About one-third of the patients also suffer from extraglandular manifestations e. READ MORE

  5. 18. The Role of Plasmacytoid Dendritic Cells and Natural Killer Cells in Systemic Lupus Erythematosus

    Author : Niklas Hagberg; Lars Rönnblom; Maija-Leena Eloranta; George Tsokos; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; plasmacytoid dendritic cells; natural killer cells; type I interferon; immune complex; SLAM receptors; autoantibodies; CD94 NKG2A; CD94 NKG2C; Medicinsk vetenskap; Medical Science; Immunologi; Immunology;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, which can eventually lead to immune complex (IC)-mediated organ damage. Due to the stimulation of plasmacytoid dendritic cells (pDC) by nucleic acid-containing ICs (DNA- or RNA-IC), patients with SLE have an ongoing interferon (IFN)-α production. READ MORE

  6. 19. Immune Cell Profiling of Colorectal Cancers: Unravelling the Connection to Treatment Responses

    Author : Azar Rezapour; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rectal cancer; Tumor infiltrating T cell; MxA; Interferon type I; CD39; CD103; PD-1; cytokines; response to the treatment;

    Abstract : Understanding the interplay between tumor cells and the immune system holds the key to the development of more effective treatments for cancer patients. Therefore, we have emphasized our efforts on deciphering the intricacies of these interactions to pave for more effective therapeutic strategies. READ MORE

  7. 20. Studies on Cardiovascular Disease in Systemic Lupus Erythematosus

    Author : Helena Tydén; Reumatologi och molekylär skelettbiologi; []
    Keywords : SLE glomerulonephritis; endothelial activation; type I interferon; S100 Proteins; Cardiovascular Disease;

    Abstract : .... READ MORE