Search for dissertations about: "Interferon"

Showing result 6 - 10 of 327 swedish dissertations containing the word Interferon.

  1. 6. Autoantibodies and the Type I Interferon System in the Etiopathogenesis of Systemic Lupus Erythematosus

    University dissertation from Uppsala University Library

    Author : Stina Blomberg; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; type I interferon; interferon inducer; dendritic cell; natural interferon-alpha producing cell; immune complex; SSA Ro; dsDNA; BDCA; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

    Abstract : In sera remitted for anti-nuclear antibody (ANA) analysis, the supplement of a sensitive anti-SSA/Ro ELISA to the conventional ANA screening by immunofluorescence (IF) revealed that one fourth of the individuals with IF-ANA negative, but SSA/Ro ELISA positive sera, had systemic lupus erythematosus (SLE) or cutaneous LE. Consequently, adding a sensitive anti-SSA/Ro ELISA to the ANA screening is valuable for the serological detection of ANA negative SLE/LE patients. READ MORE

  2. 7. Mechanisms of Interferon-α Induction in Systemic Lupus Erythematosus

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ullvi Båve; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Systemic lupus erythematosus; interferon inducer; apoptosis; autoantibodies; natural interferon-alpha producing cell; FcgammaRII; Sjögren´s syndrome; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicine; medicin;

    Abstract : Patients with systemic lupus erythematosus (SLE) have an activated type I interferon (IFN) system with an ongoing IFN-α synthesis. This may be caused by circulating immune complexes, consisting of anti-DNA antibodies (Abs) and DNA, with IFN-α inducing capacity. READ MORE

  3. 8. Interferon-alpha signaling and cell cycle regulation in neuroendocrine tumors of the digestive system

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Yinghua Zhou; Uppsala universitet.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical sciences; interferon-α; carcinoid tumors; interferon regulatory factor; p68; PKR; p21; p27; cell cycle; cyclin-dependent kinase; protein phosphorylation; protein trafficking; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : The prognosis for untreated carcinoid patients is poor and their quality of life is low. IFN-α treatment has shown a response rate of 50-80%, however, the antitumor mechanism has not been elucidated. READ MORE

  4. 9. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tanja Lövgren; Uppsala universitet.; [2006]
    Keywords : Medicine; Systemic lupus erythematosus; Sjögren s syndrome; type I interferon; plasmacytoid dendritic cell; natural interferon-producing cell; immune complex; RNP; Ro SSA; La SSB; Medicin;

    Abstract : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. READ MORE

  5. 10. On causes and regulation of anti-viral defence in asthma and COPD

    University dissertation from Lund University: Faculty of Medicine

    Author : Mandy Menzel; Lund University.; Lunds universitet.; [2018]
    Keywords : asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; ; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress; asthma; chronic obstructive pulmonary disease; rhinovirus; exacerbation; airway epithelial cell; pattern recognition receptors; interferon; allergen; azithromycin; inflammasome; epithelial-derived cytokines; oxidative stress;

    Abstract : Rhinovirus infection is a main trigger of asthma and COPD exacerbations. dsRNA, a viral replication intermediate, is sensed by pattern recognition receptors in the airway epithelium leading to down-stream induction of anti-viral interferons. READ MORE