Search for dissertations about: "Intestinal barrier"

Showing result 1 - 5 of 108 swedish dissertations containing the words Intestinal barrier.

  2. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Author : Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Abstract : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. READ MORE

  4. 2. Intestinal Mucosa Reconstitution and Protection: Impact of Luminal Factors

    Author : Yilei Mao; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Probiotics; Pectin; Oat; Methotrexate; Lactobacilli; Intestinal injury; Intestinal immunity; Intestinal barrier; Enterocolitis; Fiber; Radiation; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : The gastrointestinal mucosa is one of the most rapidly proliferating tissues in the body, and serves as a barrier to luminal bacteria and toxins. Enteral nutrition, luminal fiber and probiotics are of crucial importance for the integrity of this barrier. READ MORE

  5. 3. Challenge models and biomarkers of human intestinal barrier function

    Author : María Fernanda Roca Rubio; Julia König; Robert J Brummer; Richard Forsgård; Kaatje Lenaerts; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacterial translocation; biomarkers; challenge models; intestinal barrier function; intestinal permeability; irritable bowel syndrome; physiological stress; psychological stress;

    Abstract : The intestinal barrier is an essential component in maintaining human health, and several diseases and disorders have been associated with a disrupted intestinal barrier function. To evaluate the efficacy of different interventions intended to strengthen intestinal barrier function, there is a need for both appropriate challenge models as well as easily accessible biomarkers. READ MORE

  6. 4. Experimental Disruption of Intestinal Mucosal Homeostasis : Exploring the Protective Potential of Melatonin and Misoprostol

    Author : Karsten Peters; Markus Sjöblom; Hans Lennernäs; David Dahlgren; Åsa Keita; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intestinal barrier dysfunction; intestinal permeability; chemotherapy-induced mucositis; doxorubicin; 5-fluorouracil; apoptosis; proliferation; melatonin; misoprostol; Medicinsk vetenskap; Medical Science;

    Abstract : The intestinal mucosa serves as a protective layer that separates the intestinal contents from the underlying tissues. It restricts harmful substances, pathogens, and undigested particles from entering the bloodstream. READ MORE

  7. 5. Intestinal barrier function in health and disease

    Author : Pernilla Nejdfors; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; VIP.; PACAP; secretion; ion transport; urine reservoir; radiation therapy; ulcerative colitis; macromolecules; dextran; mannitol; Ussing chamber; Intestinal permeability; mucosa; Animal physiology; Djurfysiologi; Physiology; Fysiologi;

    Abstract : The intestinal epithelium has the dual function of absorbing nutrients and water as well as being a barrier to potentially harmful substances such as macromolecules and bacteria. In the present thesis the barrier function of the intestinal mucosa was studied in vitro in Ussing diffusion chambers. READ MORE