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Showing result 1 - 5 of 38 swedish dissertations matching the above criteria.

  2. 1. Exploring Intestinal Ischemia : An experimental study

    Author : Rolf Fröjse; Conny Arnerlöv; Ola Winsö; Stefan Lehtipalo; Eric Wahlberg; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; gastrointestinal tonometry; continuous; pig; pHi; intestinal ischemia; intestinal vascular bed; lactate; tissue oxygen tension; microdialysis; dopexamine; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : Background and aims: Unrecognized intestinal mucosal ischemia in severely ill patients may trigger development of multiple organ failure. Such ischemia can be evaluated by intraluminal tonometry reflecting mucosal PCO2 and intramucosal pH (pHi). READ MORE

  4. 2. Membrane transport and the human small intestine : Relation to mucosal protection, intestinal anaphylaxis and nitric oxide

    Author : Tina W. Knutson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; albumin; bicarbonate secretion; carbonic anhydrase; dopamine; duodenum; histamine; humans; hyaluronan; intestinal anaphylaxis; intestinal obstruction; jejunum; lidocaine; LOC-I-GUT; nitecapone; nitric oxide; potential difference; prostaglandins; segmental intestinal perfusion; Kirurgi; Surgery; Kirurgi; anestesiologi; Anaesthesiology;

    Abstract : The tightly adherent monolayer of epithelial cells that line the luminal side of the intestine provides a dynamic and highly regulated barrier to the passive and active transport of ions, water and macromolecules. Cathecol-O-methyl transferase inhibition prevents tissue degradation of catecholaminesincluding dopamine and intracellular carbonic anhydrase activity is an important regulator of ion and water transport in the small intestine. READ MORE

  5. 3. Vasopressors and intestinal mucosal perfusion

    Author : Andreas Nygren; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : .... READ MORE

  6. 4. Intestinal preservation for transplantation: translational approaches

    Author : John M. Söfteland; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal transplantation; intestinal preservation; apoptosis; tight junction; luminal preservation;

    Abstract : Background: Intestinal preservation injury (IPI) may result in various degrees of mucosal damage, which may later favor bacterial translocation, post-reperfusion syndrome, and upregulation of alloreactivity. Experimental evidence suggests that combining vascular perfusion and cold storage with luminal interventions using polyethylene glycol (PEG) solutions may mitigate the mucosal damage and extend the safe storage time. READ MORE

  7. 5. Intestinal absorption of drugs : The impact of regional permeability, nanoparticles, and absorption-modifying excipients

    Author : Carl Roos; Hans Lennernäs; Erik Sjögren; Martin Brandl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Permeability; intestinal absorption; regional permeability; nanoparticles; nanosuspensions; absorption-modifying excipients; AMEs; Biofarmaci; Biopharmaceutics;

    Abstract : For successful delivery of orally given drug products, the drug compounds must have adequate solubility and permeability in the human gastrointestinal tract. The permeability of a compound is determined by its size and lipophilicity, and is usually evaluated in various pre-clinical models, including rat models. READ MORE