Search for dissertations about: "Intracellular targeting"

Showing result 1 - 5 of 99 swedish dissertations containing the words Intracellular targeting.

  1. 1. Intracellular protein transport in plants : targeting, sorting and processing

    University dissertation from Stockholm : Stockholm University

    Author : Marie Hugosson; Stockholms universitet.; [1996]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  2. 2. Engineering of Affibody molecules for Radionuclide Molecular Imaging and Intracellular Targeting

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Camilla Hofström; KTH.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecules; affinity proteins; radionuclide molecular imaging; intracellular targeting; EGFR; HER2; IGF-1R; SRA - Molekylär biovetenskap; SRA - Molecular Bioscience;

    Abstract : Affibody molecules are small (7 kDa) affinity proteins of non-immunoglobulin origin that have been generated to specifically interact with a large number of clinically important molecular targets.In this thesis, Affibody molecules have been employed as tracers for radionuclide molecular imaging of HER2- and IGF-1R-expressing tumors, paper I-IV, and for surface knock-down of EGFR, paper V. READ MORE

  3. 3. Novel findings on cellular trafficking and targeting for granule storage of neutrophil elastase, a multifunctional effector molecule of innate immunity

    University dissertation from Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University

    Author : Linda Källquist; Lund University.; Lunds universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic cell; CD63; neutrophil elastase; targeting; trafficking; intracellular sorting; neutrophil; azurophil granule;

    Abstract : Neutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. READ MORE

  4. 4. Intracellular unbound drug concentrations Methodology and application for understanding cellular drug exposure

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : André Mateus; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intracellular unbound drug concentrations; free drug; drug binding; drug transport; drug accumulation; cellular drug response; drug target engagement; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. READ MORE

  5. 5. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

    University dissertation from Stockholm : Department of Neurochemistry

    Author : Carmine Pasquale Cerrato; Stockholms universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. READ MORE