Search for dissertations about: "Intracellular targeting"
Showing result 6 - 10 of 124 swedish dissertations containing the words Intracellular targeting.
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6. CTA1-DD; A novel vaccine adjuvant system based on ADP-ribosyltransferase activity and B cell targeting
Abstract : The ADP-ribosylating enterotoxins, cholera toxin (CT) and E. coli heat-labile toxin (LT) are among the most powerful immunogens and adjuvants yet described. An innate problem, though, is their strong toxic effects, largely due to their promiscuous binding to all nucleated cells via their B-subunits. READ MORE
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7. Aspects of Tumour Targeting : Preclinical Studies on Human Malignant Cells in vitro
Abstract : Exclusive eradication of tumour cells causing minimal damage to healthy tissue, a concept referred to as targeting, is an interesting approach to improve the outcome for patients afflicted with cancer.The general aim of this thesis was to highlighten aspects that could be of importance in developing novel treatment regimens based on specific targeting of tumour cells. READ MORE
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8. Targeting to EGF receptors : Preparation and experimental analysis of end-end coupled mEGF-dextran conjugates
Abstract : Targeted tumor therapy is to deliver cytotoxic agents selectively to tumor cells. By such delivery, normal tissues receive minimal damage while a therapeutical effect is achieved in tumor. A targetingsystem can be constructed by conjugating a tumor-seeking molecule and toxic agents via a carrier. READ MORE
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9. Engineering alternative scaffold proteins for conditional targeting
Abstract : Engineering naturally occurring proteins enables us to customize affinity domains according to our specific needs, tailoring them to become an important tool in a wide array of applications limited merely by our creativity. One of nature’s ways to regulate protein activity is by creating a functional change through alteration of a protein’s tertiary structure upon interaction with metal ions. READ MORE
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10. EGFR and HER2 Targeting for Radionuclide-Based Imaging and Therapy : Preclinical Studies
Abstract : The optimal way to detect and treat cancer is to target cancer cells exclusively without affecting the surrounding tissue. One promising approach is to use radiolabelled molecules to target receptors that are overexpressed in cancer cells. READ MORE
