Search for dissertations about: "Intrathecal administration"

Showing result 1 - 5 of 19 swedish dissertations containing the words Intrathecal administration.

  2. 1. Studies of the Biology of Intrathecal Treatment in Progressive MS

    Author : Joakim Bergman; Anders Svenningsson; A. Tommy Bergenheim; Jonathan D. Gilthorpe; Joachim Burman; Magnus Andersson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Progressive Multiple Sclerosis; intrathecal treatment; Ommaya reservoir; anti-CD20 therapy; microdialysis; cerebrospinal fluid; CNS compartments; Progressiv Multipel Skleros; intratekal behandling; Ommaya reservoar; anti-CD20 terapi; mikrodialys; ryggmärgsvätska; sektioner i centrala nervsystemet; Neurology; neurologi;

    Abstract : Background: Multiple Sclerosis (MS) is a chronic, inflammatory, autoimmune disease, affecting the central nervous system (CNS). About 85% of afflicted present with a relapsing-remitting form of the disease (RRMS), for which a breakthrough in treatment was made in 2008 with rituximab, an antibody directed towards CD20, a surface antigen on B-cells. READ MORE

  4. 2. Neuroinflammation and pain

    Author : Linda Block; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroinflammation; Pain; Persistant pain; Astrocytes; Morphine; Naloxone; Intrathecal administration;

    Abstract : ABSTRACT Background: Persistent pain that remains long after the physiological trigger has been resolved is a disabling condition. A possible mechanism for the transition from acute physiological pain to persistent pain involves low-grade inflammation in the central nervous system, in which inflammatory-activated astrocytes play a significant role. READ MORE

  5. 3. Adenosine analogues for antinociception : experimental studies in rodents on peripheral and intrathecal drug administration including assessment of spinal cord neurotoxicity

    Author : Rolf Karlsten; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  6. 4. Postoperative pain management - predictors, barriers and outcome

    Author : Kerstin Wickström Ene; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; postoperative pain management; nursing; radical prostatectomy; epidural analgesia; intrathecal analgesia; anxiety and depression; healt-related quality of life; pain predictors;

    Abstract : Despite the availability of clinical practice guidelines, effective analgesics and new technologies for drug administration, the management of postoperative pain continues to remain problematic and unsatisfactory. Nurses play an important role in the pain management. READ MORE

  7. 5. Intrathecal adenosine for treatment of acute pain : safety assessments and evaluation in experimental, surgical and labour pain

    Author : Kerstin Rane Lindgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine; intrathecal; central sensitisation; neurotoxicity; spinal cord blood flow; analgesia; anaesthetic requirement; postoperative pain; labour pain.;

    Abstract : Adenosine is an endogenous compound present in all cells in the body with a wide range of physiological effects. Exogenous administration of adenosine is used clinically as an antiarrytmic agent and as a vasodilator. READ MORE