Search for dissertations about: "Ion Mobility Spectrometry"

Showing result 1 - 5 of 17 swedish dissertations containing the words Ion Mobility Spectrometry.

  2. 1. New applications and developments of field-asymmetric ion mobility spectrometry - mass spectrometry (FAIMS-MS)

    Author : Axel Mie; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; triazine; enantiomer; ion focusing; ion mobility; FAIMS; DMS; axial ion inlet;

    Abstract : Field asymmetric ion mobility spectrometry (FAIMS), also commonly termed differential mobility spectrometry (DMS), is a gas-phase ion separation technology. FAIMS exploits differences in high-electric-field to low-electric-field ion mobility ratios to discriminate between ion species. READ MORE

  4. 2. Advances in Mass Spectrometry for the Analysis of Emerging Persistent Organic Pollutants

    Author : Lauren Gayle Mullin; Leo W. Y. Yeung; Ingrid Ericson Jogsten; Jean-François Focant; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Liquid Chromatography; Supercritical Fluid Chromatography; Ion Mobility; POPs; Electrospray Ionization;

    Abstract : Mass spectrometry (MS) is a technique widely implemented for the measurement of environmental pollutants. A critical tool for the analysis of persistent organic pollutants (POPs) over several decades, MS as coupled with liquid and gas chromatography (LC and GC) techniques enables the analysis of emerging POPs. READ MORE

  5. 3. Development and application of alternative methods for profiling proteins N-glycosylation

    Author : Alessandro Quaranta; Leopold Ilag; Niclas Karlsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; N-glycosylation; Glycomics; Glycosylation Biomarkers; Intact Glycoproteins; Glycoform Quantification; Mass Spectrometry; Ion Mobility Spectrometry; MALDI-MS; Paper Spray Ionization; Microfluidics; Magnetic Beads; Immunoaffinity Purification; Nanobodies; Analytical Chemistry; analytisk kemi;

    Abstract : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. READ MORE

  6. 4. Advanced computations and mass-spectrometric techniques to unravel the dynamics and interactions of proteins

    Author : Joana Costeira-Paulo; Erik Marklund; Lars Konermann; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; mass spectrometry; dihydroorotate dehydrogenase; alpha-synuclein; protein structure; ion mobility; electrospray ionisation; collision cross section; lipids; gas-phase hydrogen deuterium exchange; collision induced unfolding; Biokemi; Biochemistry;

    Abstract : Proteins are an important class of biomolecules, involved in the metabolism, regulation, structure and transport in cells. Unfortunately, many diseases are caused by protein dysfunction. When proteins perform their normal function, they may interact with each other or change their conformation. READ MORE

  7. 5. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

    Author : Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

    Abstract : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. READ MORE