Search for dissertations about: "Ionizable pharmaceutical"

Showing result 1 - 5 of 6 swedish dissertations containing the words Ionizable pharmaceutical.

2. 1. Potentiometric titration of ionizable compounds in two-phase systems

   Author : Per-Arne Johansson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Abstract : .... READ MORE

4. 2. Extraction of ionizable organic compounds with special emphasis on the use of adduct-forming agents

   Author : Merete Schröder-Nielsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Abstract : .... READ MORE

5. 3. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

   Author : Sibylle Neuhoff; Per Artursson; Anna-Lena Ungell; Patrick Augustijns; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

   Abstract : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. READ MORE

6. 4. Uptake and bioaccumulation of ionizable pharmaceuticals in aquatic organisms

   Author : Marja L. Boström; Enhet akvatisk ekologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antidepressiva medel; Avloppsvatten; BAF; BCF; Bioackumulation; Biokoncentration; Biomagnifikation; CYP; Extraktionsteknik; HF-LPME; Joniserbara läkemedel; Metabolism; pH; Riskanalys; Tolerans; Antidepressant; BAF; BCF; Bioaccumulation; Bioconcentration; Biomagnification; CYP; Extraction technique; HF-LPME; Ionizable pharmaceutical; Metabolism; pH; Risk assessment; Tolerance; Wastewater;

   Abstract : Pharmaceuticals are found at low concentrations (ng/L) in aquatic environments but bioaccumulation may result in aquatic organisms reaching internal effect levels (µg/L). Environmental hazard assessments include standardized bioaccumulation tests but contrary to the model substances around which the frameworks are built most pharmaceuticals are designed to mimic endogenic chemicals, ionizable, and less lipophilic. READ MORE

7. 5. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides

   Author : Matilda Lampinen Salomonsson; Mikael Hedeland; Ulf Bondesson; Calle Nilsson; Uppsala universitet; []
   Keywords : Pharmaceutical chemistry; Derivatization; mass spectrometry; glucuronide; drug metabolism; increased sensitivity; structural investigation; 2-chloro-1-methylpyridinium iodide CMPI ; 1-ethyl-3- 3-dimethylaminopropyl -carbodiimide EDC ; 2-picolylamine PA ; 1; 2-dimethylimidazole-4-sulfonyl chloride DMISC ; Farmaceutisk kemi;

   Abstract : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. READ MORE