Search for dissertations about: "Ionizable pharmaceutical"
Showing result 1 - 5 of 6 swedish dissertations containing the words Ionizable pharmaceutical.
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1. Potentiometric titration of ionizable compounds in two-phase systems
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2. Extraction of ionizable organic compounds with special emphasis on the use of adduct-forming agents
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3. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model
Abstract : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. READ MORE
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4. Uptake and bioaccumulation of ionizable pharmaceuticals in aquatic organisms
Abstract : Pharmaceuticals are found at low concentrations (ng/L) in aquatic environments but bioaccumulation may result in aquatic organisms reaching internal effect levels (µg/L). Environmental hazard assessments include standardized bioaccumulation tests but contrary to the model substances around which the frameworks are built most pharmaceuticals are designed to mimic endogenic chemicals, ionizable, and less lipophilic. READ MORE
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5. Chemical Derivatization in Combination with Liquid Chromatography Tandem Mass Spectrometry for Detection and Structural Investigation of Glucuronides
Abstract : This thesis presents novel approaches for structural investigation of glucuronides using chemical derivatization in combination with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn).Today, LC-ESI-MSn is the dominant technique for quantitative as well as qualitative analyses of metabolites, due to its high sensitivity and selectivity. READ MORE